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Cellosaurus H69/BCNU (CVCL_0B21)

[Text version]
Cell line name H69/BCNU
Accession CVCL_0B21
Resource Identification Initiative To cite this cell line use: H69/BCNU (RRID:CVCL_0B21)
Comments Selected for resistance to: ChEBI; CHEBI:3423; Carmustine (BCNU).
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=9062409; DOI=10.1038/bjc.1997.154
Jensen P.B., Holm B., Sorensen M., Christensen I.J., Sehested M.
In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin.
Br. J. Cancer 75:869-877(1997)

Cross-references
Encyclopedic resources Wikidata; Q54872200
Entry history
Entry creation10-Apr-2015
Last entry update15-Dec-2022
Version number11