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Cellosaurus Hs 895.T (CVCL_0993)

[Text version]

Cell line name Hs 895.T
Synonyms Hs-895-T; Hs 895 T; Hs895.T; Hs895T; HS895T
Accession CVCL_0993
Resource Identification Initiative To cite this cell line use: Hs 895.T (RRID:CVCL_0993)
Comments Problematic cell line: Misclassified. Originally thought to be a melanoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Doubling time: 35.2 +- 1.45 hours (PubMed=29275043).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Secretome proteome analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Skin. Cell type=Fibroblast.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.77
Native American1.02
East Asian, North0.49
East Asian, South0
South Asian0.06
European, North67.7
European, South29.96
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0992 ! Hs 895.Sk
Sex of cell Female
Age at sampling 48Y
Category Undefined cell line type
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D3S135817,18
D5S81811,12
D7S82010,12
D8S117913,15
D13S31712
D16S53912,14
D18S5112,15
D21S1130,31
FGA19,25
Penta D11,12
Penta E7,17
TH016,7
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=29275043; DOI=10.1016/j.jprot.2017.12.013
Liberato T., Pessotti D.S., Fukushima I., Kitano E.S., Serrano S.M.T., Zelanis A.
Signatures of protein expression revealed by secretome analyses of cancer associated fibroblasts and melanoma cell lines.
J. Proteomics 174:1-8(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-7637
BCRJ; 0336
Cell line databases/resources CLO; CLO_0004200
Cell_Model_Passport; SIDM01743
DepMap; ACH-000043
Biological sample resources BioSample; SAMN03472962
BioSample; SAMN10987618
Chemistry resources PharmacoDB; Hs895_T_607_2019
Encyclopedic resources Wikidata; Q54896180
Experimental variables resources EFO; EFO_0006593
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM827552
GEO; GSM887127
GEO; GSM888198
Polymorphism and mutation databases IARC_TP53; 30072
LiGeA; CCLE_078
Progenetix; CVCL_0993
Proteomic databases PRIDE; PXD007265
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number24