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Cellosaurus Hs 863.T (CVCL_0959)

[Text version]

Cell line name Hs 863.T
Synonyms Hs-863-T; Hs863T; HS863T
Accession CVCL_0959
Resource Identification Initiative To cite this cell line use: Hs 863.T (RRID:CVCL_0959)
Comments Problematic cell line: Misclassified. Originally thought to be a Ewing sarcoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Discontinued: IZSLER; BS TCL 146; probable.
Derived from sampling site: Bone. Cell type=Fibroblast.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.35
East Asian, North4.46
East Asian, South1.13
South Asian0.95
European, North67.06
European, South26.04
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 5Y
Category Undefined cell line type
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO12,13
D5S81811,12
D7S8208,13
D13S31711,12
D16S53911
TH017
TPOX8
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-7598
IZSLER; BS TCL 146
Cell line databases/resources CLO; CLO_0004166
CLDB; cl5206
Cell_Model_Passport; SIDM01726
DepMap; ACH-000119
Biological sample resources BioSample; SAMN03471165
BioSample; SAMN10988535
Chemistry resources PharmacoDB; Hs863_T_604_2019
Encyclopedic resources Wikidata; Q54896138
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887124
GEO; GSM888195
Polymorphism and mutation databases IARC_TP53; 30069
LiGeA; CCLE_050
Progenetix; CVCL_0959
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number19