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Cellosaurus Hs 675.T (CVCL_0836)

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Cell line name Hs 675.T
Synonyms Hs-675-T; Hs675T; HS675T; Hs675; 675T
Accession CVCL_0836
Resource Identification Initiative To cite this cell line use: Hs 675.T (RRID:CVCL_0836)
Comments Problematic cell line: Misclassified. Originally thought to be a colorectal carcinoma cell line but using a variety of omics methods was shown to be a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000214).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Doubling time: 6-7 days (PubMed=176412).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Fibroblast; CL=CL_0000057.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*29:02,30:02
HLA-BB*18:01,44:03
HLA-CC*05:01,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.02
East Asian, North0.97
East Asian, South0
South Asian3.25
European, North70.6
European, South25.15
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Undefined cell line type
STR profile Source(s): ATCC=CRL-7400; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D2S133824,25
D3S135816
D5S81810,12
D7S8209,10
D8S117914
D13S31710,14
D16S53911
D18S5112,16
D19S43316,16.2
D21S1129,32.2
FGA20,26
Penta D9,10
Penta E5,11
TH017,9.3
TPOX9 (PubMed=25877200)
9,12 (ATCC=CRL-7400)
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=176412; DOI=10.1093/jnci/56.4.843
Robert B. Owens, Helene S. Smith, Walter Anthony Nelson-Rees, E. Louise Springer;
Epithelial cell cultures from normal and cancerous human tissues.
J. Natl. Cancer Inst. 56:843-849(1976)

PubMed=283258; DOI=10.1093/jnci/62.2.225
Helene S. Smith;
In vitro properties of epithelial cell lines established from human carcinomas and nonmalignant tissue.
J. Natl. Cancer Inst. 62:225-230(1979)

PubMed=761205
Helene S. Smith, E. Louise Springer, Adeline Johnson Hackett;
Nuclear ultrastructure of epithelial cell lines derived from human carcinomas and nonmalignant tissues.
Cancer Res. 39:332-344(1979)

PubMed=22282976; DOI=10.1093/carcin/1.1.21
Rufus S. Day 3rd, Chuck H.J. Ziolkowski, Dominic A. Scudiero, Sharon A. Meyer, Michael R. Mattern;
Human tumor cell strains defective in the repair of alkylation damage.
Carcinogenesis 1:21-32(1980)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

DOI=10.1101/166199
Antoine de Weck, Hans Bitter, Audrey Kauffmann;
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-7400
Cell line databases/resources CLO; CLO_0004038
cancercelllines; CVCL_0836
Cell_Model_Passport; SIDM01564
ColonAtlas; Hs%20675.T
DepMap; ACH-000214
Biological sample resources BioSample; SAMN03471493
BioSample; SAMN03473156
BioSample; SAMN10988123
Chemistry resources PharmacoDB; Hs675_T_583_2019
Encyclopedic resources Wikidata; Q54895856
Experimental variables resources EFO; EFO_0006587
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM887105
GEO; GSM888176
Polymorphism and mutation databases IARC_TP53; 30055
LiGeA; CCLE_230
Progenetix; CVCL_0836
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number30