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Cellosaurus Hs 618.T (CVCL_0827)

[Text version]

Cell line name Hs 618.T
Synonyms Hs-618-T; Hs618T; HS618T; 618T
Accession CVCL_0827
Resource Identification Initiative To cite this cell line use: Hs 618.T (RRID:CVCL_0827)
Comments Problematic cell line: Misclassified. Originally thought to be a lung adenocarcinoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Lung. Cell type=Fibroblast.
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.37
Native American21.61
East Asian, North1.07
East Asian, South1.4
South Asian1.63
European, North38.2
European, South33.72
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S304 ! Hs 618.Lu
Sex of cell Female
Age at sampling 60Y
Category Undefined cell line type
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO12
D5S8189,10
D7S82012,14
D13S31712,13
D16S53911,12
TH017,10
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=7171457; DOI=10.1038/bjc.1982.272
Brown D.T., Moore M.
Monoclonal antibodies against two human lung carcinoma cell lines.
Br. J. Cancer 46:794-801(1982)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-7380 - Discontinued
ATCC; CRL-7380_FL - Discontinued
Cell line databases/resources CLO; CLO_0004029
Cell_Model_Passport; SIDM01565
DepMap; ACH-000539
Biological sample resources BioSample; SAMN03471490
BioSample; SAMN10987679
Chemistry resources PharmacoDB; Hs618_T_582_2019
Encyclopedic resources Wikidata; Q54895825
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887104
GEO; GSM888175
Polymorphism and mutation databases IARC_TP53; 30054
LiGeA; CCLE_832
Progenetix; CVCL_0827
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number20