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Cellosaurus Hs 578Bst (CVCL_0807)

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Cell line name Hs 578Bst
Synonyms Hs578Bst; HS578BST; Hs-578Bst; Hs 578.Bst; Homo sapiens No. 578, breast cells
Accession CVCL_0807
Resource Identification Initiative To cite this cell line use: Hs 578Bst (RRID:CVCL_0807)
Comments Part of: ICBP43 breast cancer cell line panel.
Population: Caucasian.
Omics: Genomics; Mitochondrial genome sequencing.
Caution: Although it is part of a cancer cell line panel, it is a normal fibroblastic epithelial/myoepithelial cell line.
Misspelling: Hs57Bst; DOI=10.1016/B978-0-12-333530-2.50009-5.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:7427; MT-CYB; Simple; p.Ala125Thr (m.15119G>A); ClinVar=VCV000693829; Zygosity=Heteroplasmic; Note=Less <1% while homoplasmic in autologous cell line Hs 578T (PubMed=29671673).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S253 ! Hs 578.Mg
CVCL_0332 ! Hs 578T
Sex of cell Female
Age at sampling 74Y
Category Finite cell line
STR profile Source(s): ATCC=HTB-125

Markers:
AmelogeninX
CSF1PO11,13
D2S133817,26
D3S135816,17
D5S81811,13
D7S82010
D8S117913
D13S31711,13
D16S5399,12
D18S5116
D19S43314,15
D21S1129,32.2
FGA23,24
Penta D8,13
Penta E13,14
TH019,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/
Publications

PubMed=864756; DOI=10.1093/jnci/58.6.1795
Adeline Johnson Hackett, Helene S. Smith, E. Louise Springer, Robert B. Owens, Walter Anthony Nelson-Rees, John L. Riggs, Murray B. Gardner;
Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines.
J. Natl. Cancer Inst. 58:1795-1806(1977)

DOI=10.1016/B978-0-12-333530-2.50009-5
Albert Leibovitz;
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=29671673; DOI=10.1080/24701394.2018.1461852
Annica Hedberg, Erik Knutsen, Anne Silje Lovhaugen, Tor Erik Jorgensen, Maria Perander, Steinar D. Johansen;
Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair.
Mitochondrial DNA A. DNA Mapp. Seq. Anal. 30:82-91(2019)

Cross-references
Cell line collections (Providers) ATCC; HTB-125
IZSLER; BS CL 190
Cell line databases/resources CLO; CLO_0004008
CLDB; cl1715
CCRID; 3101HUMGNHu16
Anatomy/cell type resources BTO; BTO_0003886
Biological sample resources BioSample; SAMN03471102
Chemistry resources PharmacoDB; HS578BST_617_2019
Encyclopedic resources Wikidata; Q54895773
Experimental variables resources EFO; EFO_0022653
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29