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Cellosaurus Hs 445 (CVCL_0761)

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Cell line name Hs 445
Synonyms HS-445; Hs-445; HS 445T; Hs445; HS445
Accession CVCL_0761
Resource Identification Initiative To cite this cell line use: Hs 445 (RRID:CVCL_0761)
Comments Problematic cell line: Misclassified. Originally thought to be a Hodgkin lymphoma cell line but is a B-lymphoblastoid cell line (PubMed=12592342; PubMed=29533902).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lymph node; UBERON=UBERON_0000029.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.48
Native American0
East Asian, North1.04
East Asian, South0.01
South Asian0
European, North63.69
European, South34.78
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 56Y
Category Transformed cell line
STR profile Source(s): ATCC=HTB-146; Cosmic-CLP=1322218

Markers:
AmelogeninX
CSF1PO10.3,11 (ATCC=HTB-146)
11 (Cosmic-CLP=1322218)
D2S133820,24
D3S135816,18
D5S8189,12
D7S8209,10
D8S117914
D13S31711,13
D16S5399 (Cosmic-CLP=1322218)
9,11 (ATCC=HTB-146)
D18S5113,15
D19S43314
D21S1129,31
FGA24,26
Penta D10,11
Penta E12,14
TH016,7
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=6500159; DOI=10.1159/000163283
Merrill Eric Gershwin, Daniel Lentz, Robert B. Owens;
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Marcin Majka, Tomasz Rozmyslowicz, Marek J. Honczarenko, Janina Ratajczak, Mariusz A. Wasik, Glen N. Gaulton, Mariusz Zdzislaw Ratajczak;
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Hans Gunther Drexler, Claudia Pommerenke, Sonja Eberth, Stefan Nagel;
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; HTB-146
Cell line databases/resources CLO; CLO_0003962
Cell_Model_Passport; SIDM00668
Cosmic-CLP; 1322218
DepMap; ACH-002245
LINCS_LDP; LCL-2006
Biological sample resources BioSample; SAMN03472720
Chemistry resources GDSC; 1322218
PharmacoDB; Hs445_613_2019
Encyclopedic resources Wikidata; Q54895678
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669894
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number33