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Cellosaurus MDA-MB-330 (CVCL_0619)

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Cell line name MDA-MB-330
Synonyms MDAMB330; MDA-330; MDA330; MD Anderson-Metastatic Breast-330
Accession CVCL_0619
Resource Identification Initiative To cite this cell line use: MDA-MB-330 (RRID:CVCL_0619)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 1.7 days (PubMed=9671407).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.4
Native American0
East Asian, North2.68
East Asian, South0
South Asian0
European, North67.3
European, South29.63
Disease Invasive breast lobular carcinoma (NCIt: C7950)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-127; Cosmic-CLP=1330941; DepMap=ACH-001358; PubMed=25877200; PubMed=28889351

Markers:
AmelogeninX
CSF1PO10
D2S133818
D3S135817
D5S81813
D7S82010,11
D8S117913,15
D13S3179
D16S5399,12
D18S5121
D19S43315,15.2
D21S1129
FGA21,22
Penta D9,14
Penta E12,13,17
TH018,9.3
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=730202; DOI=10.1007/BF02616120
Relda Marie Cailleau, Matilde Olive, Quita V.J. Cruciger;
Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization.
In Vitro 14:911-915(1978)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

DOI=10.1016/B978-0-12-333530-2.50009-5
Albert Leibovitz;
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=9671407; DOI=10.1038/sj.onc.1201814
Kimberley J. Sweeney, Alexander Swarbrick, Robert Lyndsay Sutherland, Elizabeth A. Musgrove;
Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells.
Oncogene 16:2865-2878(1998)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Fons Elstrodt, Antoinette Hollestelle, Jord H.A. Nagel, Michael Gorin, Marijke Wasielewski, Ans M.W. van den Ouweland, Sofia Diana Merajver, Stephen P. Ethier, Mieke Schutte;
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Marijke Wasielewski, Fons Elstrodt, Jan G.M. Klijn, Els M.J.J. Berns, Mieke Schutte;
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

DOI=10.25904/1912/1434
Brian J. Morrison;
Breast cancer stem cells: tumourspheres and implications for therapy.
Thesis PhD (2010); Griffith University; Brisbane; Australia

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Antoinette Hollestelle, Jord H.A. Nagel, Marcel Smid, Suzanne Lam, Fons Elstrodt, Marijke Wasielewski, Ser Sue Ng, Pim J. French, Justine K. Peeters, Marieke J. Rozendaal, Muhammad Riaz ...Show all 26 authors... , Daphne G. Koopman, Timo L.M. ten Hagen, Bertie H.C.G.M. de Leeuw, Ellen C. Zwarthoff, Amina F.A.S. Teunisse, Peter J. van der Spek, Jan G.M. Klijn, Winand N.M. Dinjens, Stephen P. Ethier, Hans Cornelius Clevers, Aart G. Jochemsen, Michael A. den Bakker, John A. Foekens, John W.M. Martens, Mieke Schutte; Show fewer authors
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Muhammad Riaz, Marijn T.M. van Jaarsveld, Antoinette Hollestelle, Wendy J.C. Prager-van der Smissen, Anouk A.J. Heine, Antonius W.M. Boersma, Jing-Jing Liu, Jean C.A. Helmijr, Bahar Ozturk, Marcel Smid, Erik A.C. Wiemer ...Show all 13 authors... , John A. Foekens, John W.M. Martens; Show fewer authors
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25757734; DOI=10.1186/s13058-015-0517-z; PMCID=PMC4320436
Matthias Christgen, Patrick W.B. Derksen;
Lobular breast cancer: molecular basis, mouse and cellular models.
Breast Cancer Res. 17:16.1-16.9(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Jodi M. Saunus, Chanel E. Smart, Jamie R. Kutasovic, Rebecca L. Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N. Rozali, Ana Cristina Vargas, Lynne E. Reid, Eva Lorsy, Sibylle Cocciardi ...Show all 23 authors... , Tatjana Seidens, Amy Ellen McCart Reed, Andrew J. Dalley, Leesa F. Wockner, Julie Johnson, Debina Sarkar, Marjan E. Askarian-Amiri, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R. Lakhani; Show fewer authors
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

PubMed=30228172; DOI=10.1158/0008-5472.CAN-18-1416; PMCID=PMC6507416
Nilgun Tasdemir, Emily Ann Bossart, Zhe-Qi Li, Li Zhu, Matthew J. Sikora, Kevin M. Levine, Britta M. Jacobsen, George Chien-Cheng Tseng, Nancy E. Davidson, Steffi Oesterreich;
Comprehensive phenotypic characterization of human invasive lobular carcinoma cell lines in 2D and 3D cultures.
Cancer Res. 78:6209-6222(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; HTB-127
Cell line databases/resources CLO; CLO_0007635
cancercelllines; CVCL_0619
Cell_Model_Passport; SIDM00631
Cosmic-CLP; 1330941
DepMap; ACH-001358
LINCS_LDP; LCL-1961
Biological sample resources BioSample; SAMN03473067
Chemistry resources GDSC; 1330941
PharmacoDB; MDAMB330_901_2019
Encyclopedic resources Wikidata; Q54904624
Experimental variables resources EFO; EFO_0006454
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM421874
GEO; GSM783951
GEO; GSM1661982
GEO; GSM1670081
Polymorphism and mutation databases Cosmic; 871154
Cosmic; 904378
Cosmic; 934537
Cosmic; 979725
Cosmic; 997918
Cosmic; 1046956
Cosmic; 1152521
Cosmic; 1287917
Cosmic; 1289396
Cosmic; 1603219
IARC_TP53; 24350
Progenetix; CVCL_0619
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42