Home  |  Contact
Due to maintenance work, this service will be unavailable Mon Feb 13 between 07:00 and 09:30 - CET. Apologies for the inconvenience.

Cellosaurus WM35 (CVCL_0580)

[Text version]

Cell line name WM35
Synonyms WM-35; WM 35; WC00060
Accession CVCL_0580
Resource Identification Initiative To cite this cell line use: WM35 (RRID:CVCL_0580)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Wistar Institute melanoma cell line collection.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: D18S51: 20->14,15 and FGA: 19->19,24.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=18632627; Cosmic-CLP; DepMap; Wistar).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North0.26
East Asian, South0.38
South Asian0.25
European, North72.7
European, South26.42
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A806 (WM35-P1N1)CVCL_A807 (WM35-P1N2)CVCL_A808 (WM35-P1N3)
CVCL_A809 (WM35-P2N1)CVCL_A810 (WM35-P2N2)CVCL_A811 (WM35-P2N3)
Sex of cell Female
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=27087056; Wistar


Run an STR similarity search on this cell line
Web pages https://web.archive.org/web/20141129125241/http://www.wistar.org:80/lab/meenhard-herlyn-dvm-dsc/page/melanoma-cell-lines-0

PubMed=2253310; DOI=10.1007/BF00046337
Herlyn M.
Human melanoma: development and progression.
Cancer Metastasis Rev. 9:101-112(1990)

PubMed=2068080; DOI=10.1073/pnas.88.14.6028
Cornil I., Theodorescu D., Man S., Herlyn M., Jambrosic J.A., Kerbel R.S.
Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.
Proc. Natl. Acad. Sci. U.S.A. 88:6028-6032(1991)

PubMed=11123321; DOI=10.4049/jimmunol.166.1.432
Li J., Pereira S., Van Belle P., Tsui P., Elder D., Speicher D., Deen K., Linnenbach A., Somasundaram R., Swoboda R., Herlyn D.
Isolation of the melanoma-associated antigen p23 using antibody phage display.
J. Immunol. 166:432-438(2001)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M.W., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=18790768; DOI=10.1158/1535-7163.MCT-08-0431
Smalley K.S.M., Lioni M., Dalla Palma M., Xiao M., Desai B., Egyhazi S., Hansson J., Wu H., King A.J., Van Belle P., Elder D.E., Flaherty K.T., Herlyn M., Nathanson K.L.
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Mol. Cancer Ther. 7:2876-2883(2008)

PubMed=23039341; DOI=10.1186/1476-4598-11-75
Byron S.A., Loch D.C., Wellens C.L., Wortmann A., Wu J., Wang J., Nomoto K., Pollock P.M.
Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status.
Mol. Cancer 11:75.1-75.15(2012)

PubMed=27087056; DOI=10.1038/srep24569
Haridas P., McGovern J.A., Kashyap A.S., McElwain D.L.S., Simpson M.J.
Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.
Sci. Rep. 6:24569-24569(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections ATCC; CRL-2807 - Discontinued
Coriell; WC00060 - Discontinued
Cell line databases/resources CLO; CLO_0009617
MCCL; MCC:0000486
Cell_Model_Passport; SIDM00974
Cosmic-CLP; 1299080
DepMap; ACH-002207
Lonza; 583
Anatomy/cell type resources BTO; BTO:0003475
Biological sample resources BioSample; SAMN03471793
Chemistry resources GDSC; 1299080
PharmacoDB; WM35_1672_2019
Encyclopedic resources Wikidata; Q54994256
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM109040
GEO; GSM186484
GEO; GSM186485
GEO; GSM188068
GEO; GSM188120
GEO; GSM188193
GEO; GSM188208
GEO; GSM188213
GEO; GSM188284
GEO; GSM188293
GEO; GSM555119
GEO; GSM555188
GEO; GSM952586
GEO; GSM1670580
Polymorphism and mutation databases Cosmic; 686396
Cosmic; 886834
Cosmic; 1155548
Cosmic; 1187584
Cosmic; 1247866
Cosmic; 1303075
Cosmic; 1507600
Cosmic; 1995666
Cosmic; 2159431
Progenetix; CVCL_0580
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number30