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Cellosaurus SaOS-LM7 (CVCL_0515)

[Text version]
Cell line name SaOS-LM7
Synonyms SAOS-LM7; Saos-LM7; SaOs-lm7; SaOS/LM7; LM7
Accession CVCL_0515
Resource Identification Initiative To cite this cell line use: SaOS-LM7 (RRID:CVCL_0515)
Comments Population: Caucasian.
Characteristics: Metastatic. Established by 7 cycling of parent cell line through the lungs of nude mice.
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9568 (SaOS-LM6)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=22075555; DOI=10.1158/0008-5472.CAN-11-2778; PMCID=PMC3833671
Gang-Xiong Huang, Ling Yu, Laurence J.N. Cooper, Mario Hollomon, Helen Huls, Eugenie S. Kleinerman;
Genetically modified T cells targeting interleukin-11 receptor alpha-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases.
Cancer Res. 72:271-281(2012)

PubMed=22186140; DOI=10.1158/0008-5472.CAN-11-1460; PMCID=PMC3288434
Gang-Xiong Huang, Kazumasa Nishimoto, Zhi-Chao Zhou, Dennis Patrick Meehan Hughes, Eugenie S. Kleinerman;
miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression.
Cancer Res. 72:908-916(2012)

PubMed=24136885; DOI=10.1002/pbc.24801; PMCID=PMC4154381
Sergei R. Guma, Dean Anthony Lee, Ling Yu, Nancy Gordon, Dennis Patrick Meehan Hughes, John Stewart, Wei-Lien Wang, Eugenie S. Kleinerman;
Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis.
Pediatr. Blood Cancer 61:618-626(2014)

PubMed=26320182; DOI=10.18632/oncotarget.5177; PMCID=PMC4745740
Ling Ren, Arnulfo Mendoza, Jack Zhu, Joseph W. Briggs, Charles Halsey, Ellen S. Hong, Sandra Sczerba Burkett, James J. Morrow, Michael M. Lizardo, Tanasa Osborne, Samuel Q. Li ...Show all 14 authors... , Hue H. Luu, Paul S. Meltzer, Chand Khanna; Show fewer authors
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)

PubMed=29334376; DOI=10.1038/nm.4475; PMCID=PMC5803371
James J. Morrow, Ian Bayles, Alister Peter William Funnell, Tyler Eugene Miller, Alina Saiakhova, Michael M. Lizardo, Cynthia F. Bartels, Maaike Y. Kapteijn, Stevephen Hung, Arnulfo Mendoza, Gursimran Dhillon ...Show all 26 authors... , Daniel R. Chee, Jay T. Myers, Frederick Allen, Marco Gambarotti, Alberto Righi, Analisa DiFeo, Brian P. Rubin, Alex Y. Huang, Paul S. Meltzer, Lee J. Helman, Piero Picci, Hendrik Henri Versteeg, John A. Stamatoyannopoulos, Chand Khanna, Peter C. Scacheri; Show fewer authors
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
Nat. Med. 24:176-185(2018)

Cross-references
Cell line databases/resources MCCL; MCC:0000413
Encyclopedic resources Wikidata; Q54952110
Gene expression databases GEO; GSM1914992
GEO; GSM1914993
GEO; GSM1914994
GEO; GSM1914995
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number18