Cellosaurus cell line NKL (CVCL

Cellosaurus NKL (CVCL_0466)

Cross-references
Cell line name	NKL
Accession	CVCL_0466
Resource Identification Initiative	To cite this cell line use: NKL (RRID:CVCL_0466)
Comments	Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Characteristics: IL2 dependent. Doubling time: 24-48 hours (PubMed=8599969). Omics: Transcriptomics; Microarray. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Natural killer cell; CL=CL_0000623.
Disease	Natural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	63Y
Category	Cancer cell line
Publications	PubMed=8599969 Michael J. Robertson, Keith J. Cochran, Christine Cameron, Jeannette-MyLe Le, Ramana Tantravahi, Jerome Ritz; Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. Exp. Hematol. 24:406-415(1996) PubMed=10803505; DOI=10.1038/sj.leu.2401778 Hans Gunther Drexler, Yoshinobu Matsuo; Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma. Leukemia 14:777-782(2000) DOI=10.1016/B978-0-12-221970-2.50457-5 Hans Gunther Drexler; The leukemia-lymphoma cell line factsbook. (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001) PubMed=30054012; DOI=10.1016/j.molimm.2018.07.015; PMCID=PMC6345623 Justin Tyme Gunesch, Laura S. Angelo, Sanjana Mahapatra, Raquel Payzant Deering, Johanna E. Kowalko, Patrick Sleiman, John W. Tobias, Linda Monaco-Shawver, Jordan Scott Orange, Emily M. Mace; Genome-wide analyses and functional profiling of human NK cell lines. Mol. Immunol. 115:64-75(2019)
Cell line databases/resources	MCCL; MCC:0000364 cancercelllines; CVCL_0466 Cell_Model_Passport; SIDM01880 DepMap; ACH-001143 Lonza; 145
Encyclopedic resources	Wikidata; Q54930680
Experimental variables resources	EFO; EFO_0022550
Polymorphism and mutation databases	Cosmic; 1534875 Cosmic; 2025324 Cosmic; 2785207
Entry history
Entry creation	04-Apr-2012
Last entry update	10-Apr-2025
Version number	17