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Cellosaurus MIO-M1 (CVCL_0433)

[Text version]
Cell line name MIO-M1
Synonyms Moorfields/Institute of Ophthalmology-Muller 1
Accession CVCL_0433
Resource Identification Initiative To cite this cell line use: MIO-M1 (RRID:CVCL_0433)
Comments Omics: Metabolomics.
Omics: Proteomics.
Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
Cell type: Muller glia; CL=CL_0000636.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Spontaneously immortalized cell line
Web pages Provider; UCLB; -; https://xip.uclb.com/product/MIO_M1_cells
Publications

PubMed=11867609
Gloria Astrid Limb, Thomas E. Salt, Peter M.G. Munro, Stephen E. Moss, Peng Tee Khaw;
In vitro characterization of a spontaneously immortalized human Muller cell line (MIO-M1).
Invest. Ophthalmol. Vis. Sci. 43:864-869(2002)

PubMed=17525239; DOI=10.1634/stemcells.2006-0724
Jean M. Lawrence, Shweta Singhal, Bhairavi Bhatia, David J. Keegan, Thomas A. Reh, Philip J. Luthert, Peng Tee Khaw, Gloria Astrid Limb;
MIO-M1 cells and similar Muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics.
Stem Cells 25:2033-2043(2007)

PubMed=22065927; PMCID=PMC3209432
Margrit Hollborn, Elke Ulbricht, Katja Rillich, Sladjana Dukic-Stefanovic, Antje Wurm, Lysann Wagner, Andreas Reichenbach, Peter Wiedemann, Gloria Astrid Limb, Andreas Bringmann, Leon Kohen;
The human Muller cell line MIO-M1 expresses opsins.
Mol. Vis. 17:2738-2750(2011)

PubMed=30176221; DOI=10.1016/j.exer.2018.08.016; PMCID=PMC6280037
Karen Eastlake, Wendy E. Heywood, Phillip Banerjee, Emily Bliss, Kevin Mills, Peng Tee Khaw, David Charteris, Gloria Astrid Limb;
Comparative proteomic analysis of normal and gliotic PVR retina and contribution of Muller glia to this profile.
Exp. Eye Res. 177:197-207(2018)

PubMed=31254428; DOI=10.1111/ceo.13578
Rachel Churm, Gareth J. Dunseath, Sarah L. Prior, Rebecca L. Thomas, Sanjiv Banerjee, David R. Owens;
Development and characterization of an in vitro system of the human retina using cultured cell lines.
Clin. Exp. Ophthalmol. 47:1055-1062(2019)

PubMed=32152301; DOI=10.1038/s41467-020-15066-6; PMCID=PMC7062830
Charandeep Singh, Vincent Tran, Leah McCollum, Youstina Bolok, Kristin Allan, Alex Yuan, George Hoppe, Henri Brunengraber, Jonathan E. Sears;
Hyperoxia induces glutamine-fuelled anaplerosis in retinal Muller cells.
Nat. Commun. 11:1277.1-1277.11(2020)

Cross-references
Cell line databases/resources MCCL; MCC:0000328
Anatomy/cell type resources BTO; BTO_0003062
Encyclopedic resources Wikidata; Q54905749
Metabolomic databases MetaboLights; MTBLS1228
Proteomic databases PRIDE; PXD008485
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number15