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Cellosaurus MIN6 (CVCL_0431)

[Text version]
Cell line name MIN6
Synonyms Min6; MIN-6; Mouse INsulinoma 6
Accession CVCL_0431
Resource Identification Initiative To cite this cell line use: MIN6 (RRID:CVCL_0431)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Proteomics; Subcellular; Cell surface.
Omics: Proteomics; Subcellular; Endoplasmic reticulum.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Mouse insulinoma (NCIt: C34053)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 IT6 transgenic.
Hierarchy Children:
CVCL_A7QH (MIN6 rho0)CVCL_A8QH (MIN6-cl4)CVCL_4372 (MIN6-m14)
CVCL_4371 (MIN6-m9)CVCL_D686 (MIN6N8)
Sex of cell Sex unspecified
Age at sampling 13W
Category Transformed cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-93.html
Publications

PubMed=2163307; DOI=10.1210/endo-127-1-126
Jun-ichi Miyazaki, Kimi Araki, Eiji Yamato, Hiroshi Ikegami, Tomoichiro Asano, Yoshikazu Shibasaki, Yoshitomo Oka, Ken-ichi Yamamura;
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms.
Endocrinology 127:126-132(1990)

PubMed=8697299
Vincent Poitout, Lawrence Karl Olson, R. Paul Robertson;
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)

PubMed=8824267; DOI=10.1074/jbc.271.42.26194
Aki Soejima, Kimiko Inoue, Daisaku Takai, Motohisa Kaneko, Hisamitsu Ishihara, Yoshitomo Oka, Jun-ichi Hayashi;
Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6.
J. Biol. Chem. 271:26194-26199(1996)

PubMed=18845907; DOI=10.1507/endocrj.K08E-172
Koji Nakashima, Yukiko Kanda, Yasushi Hirokawa, Fumiko Kawasaki, Michihiro Matsuki, Kohei Kaku;
MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones.
Endocr. J. 56:45-53(2009)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=22808281; DOI=10.1371/journal.pone.0040868; PMCID=PMC3396628
Kim Cheng, Viviane Delghingaro-Augusto, Christopher J. Nolan, Nigel Turner, Nicole Hallahan, Sofianos Andrikopoulos, Jenny Elizabeth Gunton;
High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.
PLoS ONE 7:e40868.1-e40868.12(2012)

PubMed=23560115; DOI=10.1371/journal.pone.0061211; PMCID=PMC3616144
Eiji Yamato, Fumi Tashiro, Jun-ichi Miyazaki;
Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic beta cell line MIN6.
PLoS ONE 8:e61211.1-e61211.12(2013)

PubMed=25546123; DOI=10.1002/pmic.201400345; PMCID=PMC4489703
Jin-Sook Lee, Yan-Ning Wu, Patricia Schnepp, Jing-Ye Fang, Xue-Bao Zhang, Alla Karnovsky, James Woods, Paul M. Stemmer, Ming Liu, Ke-Zhong Zhang, Xue-Qun Chen;
Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells.
Proteomics 15:1508-1511(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347
Damaris Bausch-Fluck, Andreas Hofmann, Thomas Bock, Andreas P. Frei, Ferdinando Cerciello, Andrea Jacobs, Hansjoerg Moest, Ulrich Omasits, Rebekah L. Gundry, Charles Yoon, Ralph Schiess ...Show all 20 authors... , Alexander Schmidt, Paulina Mirkowska, Anetta Svitorka Hartlova, Jennifer Eileen Van Eyk, Jean-Pierre Bourquin, Rudolf Aebersold, Kenneth R. Boheler, Peter W. Zandstra, Bernd Wollscheid; Show fewer authors
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:e0121314.1-e0121314.22(2015)

Cross-references
Cell line collections (Providers) AddexBio; C0018008/403
BCRJ; 0293
CLS; 302148
IBRC; C10524
Cell line databases/resources MCCL; MCC:0000326
Lonza; 163
Anatomy/cell type resources BTO; BTO_0002284
Chemistry resources ChEMBL-Cells; CHEMBL4483177
ChEMBL-Targets; CHEMBL4483258
PubChem_Cell_line; CVCL_0431
Encyclopedic resources Wikidata; Q12513178
Experimental variables resources EFO; EFO_0002829
Proteomic databases PRIDE; PXD000589
PRIDE; PXD001081
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26