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Cellosaurus Mahlavu (CVCL_0405)

[Text version]
Cell line name Mahlavu
Synonyms MAHLAVU
Accession CVCL_0405
Resource Identification Initiative To cite this cell line use: Mahlavu (RRID:CVCL_0405)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Population: African.
Doubling time: 22.5 hours (CelloPub=CLPUB00076); 52.01 hours (PubMed=31378681).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Misspelling: Malhavu; Note=Occasionally.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
Disease Hepatocellular carcinoma (NCIt: C3099)
Hepatocellular carcinoma (ORDO: Orphanet_88673)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CLS=300473; PubMed=31378681

Markers:
AmelogeninX
CSF1PO7,11
D2S133819,22
D3S135817
D5S81812
D6S104312
D7S82010,11
D8S117911,14
D12S39118
D13S31712,13
D16S53911
D18S5115
D19S43311,14
D21S1131.2,32.2
FGA28
Penta D9,11
Penta E8,11
TH017
TPOX8,10
vWA15

Run an STR similarity search on this cell line
Web pages Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/Mahlavu
Provider; BRICS; BRICS0078; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3892
Publications

CLPUB00076
Otto Walter Prozesky, Charlotte J. Brits, Wilhelm Otto Karl Grabow;
In vitro culture of cell lines from Australia antigen positive and negative hepatoma patients.
(In book chapter) Liver; Saunders, Stuart John & Terblanche, John (eds.); pp.358-360; Pitman Medical Books; London; United Kingdom (1973)

CLPUB00575
Otto Walter Prozesky, Gerasimos Lecatsas;
Scanning electron microscopy of a human hepatoma cell line.
S. Afr. Med. J. 49:1061-1062(1975)

PubMed=179808; DOI=10.1111/j.1432-1033.1976.tb10294.x
Johanna Grimm;
The influence of insulin on various enzyme activities in human and rat hepatoma cells.
Eur. J. Biochem. 64:249-253(1976)

PubMed=6268737; DOI=10.1099/0022-1317-53-1-105
Paul E. Oefinger, David Leigh Bronson, Gordon R. Dreesman;
Induction of hepatitis B surface antigen in human hepatoma-derived cell lines.
J. Gen. Virol. 53:105-113(1981)

PubMed=6275024; DOI=10.1099/0022-1317-57-1-95
Rajen Koshy, Philippe Maupas, R. Muller, Peter Hans Hofschneider;
Detection of hepatitis B virus-specific DNA in the genomes of human hepatocellular carcinoma and liver cirrhosis tissues.
J. Gen. Virol. 57:95-102(1981)

DOI=10.1007/978-4-431-68349-0_4
Jennifer J. Alexander;
Human hepatoma cell lines.
(In book chapter) Neoplasms of the liver; Okuda, Kunio & Ishak, Kamal George (eds.); pp.47-56; Springer; Tokyo; Japan (1987)

PubMed=2439335; DOI=10.1111/j.1432-1033.1987.tb11497.x
Claude Vincent, Marianne Marceau, Pascale Blangarin, Patrick Bouic, Jean-Jacques Madjar, Jean-Pierre Revillard;
Purification of alpha 1-microglobulin produced by human hepatoma cell lines. Biochemical characterization and comparison with alpha 1-microglobulin synthesized by human hepatocytes.
Eur. J. Biochem. 165:699-704(1987)

PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613
Alain Puisieux, Katherine Galvin, Frederic Troalen, Brigitte Bressac, Christophe Marcais, Eithan Galun, Frederique Ponchel, Cengiz Yakicier, Jing-Wei Ji, Mehmet Ozturk;
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
FASEB J. 7:1407-1413(1993)

PubMed=8050184; DOI=10.1111/j.1365-2249.1994.tb06089.x; PMCID=PMC1534706
Ahmed Abdulhay Wadee, Alan Paterson, Keren Anne Coplan, Selvan G. Reddy;
HLA expression in hepatocellular carcinoma cell lines.
Clin. Exp. Immunol. 97:328-333(1994)

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Jean-Charles Nault, Maxime Mallet, Camilla Pilati, Julien Calderaro, Paulette Bioulac-Sage, Christophe Laurent, Alexis Laurent, Daniel Cherqui, Charles Balabaud, Jessica Zucman-Rossi;
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350
Dilek Cevik, Gokhan Yildiz, Mehmet Ozturk;
Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations.
World J. Gastroenterol. 21:311-317(2015)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Stefano Caruso, Anna-Line Calatayud, Jill Pilet, Tiziana La Bella, Samia Rekik, Sandrine Imbeaud, Eric Letouze, Lea Meunier, Quentin Bayard, Nataliya Rohr-Udilova, Camille Peneau ...Show all 20 authors... , Bettina Grasl-Kraupp, Leanne de Koning, Berengere Ouine, Paulette Bioulac-Sage, Gabrielle Couchy, Julien Calderaro, Jean-Charles Nault, Jessica Zucman-Rossi, Sandra Rebouissou; Show fewer authors
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Zhi-Xin Qiu, Hong Li, Zheng-Tao Zhang, Zhen-Feng Zhu, Sheng He, Xu-Jun Wang, Peng-Cheng Wang, Jian-Jie Qin, Li-Ping Zhuang, Wei Wang, Fu-Bo Xie ...Show all 33 authors... , Ying Gu, Ke-Ke Zou, Chao Li, Chun Li, Chen-Hua Wang, Jin Cen, Xiao-Tao Chen, Ya-Jing Shu, Zhao Zhang, Lu-Lu Sun, Li-Hua Min, Yong Fu, Xiao-Wu Huang, Hui Lv, He Zhou, Yuan Ji, Zhi-Gang Zhang, Zhi-Qiang Meng, Xiao-Lei Shi, Hai-Bin Zhang, Yi-Xue Li, Li-Jian Hui; Show fewer authors
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line collections (Providers) CLS; 300473
Cell line databases/resources MCCL; MCC:0000299
cancercelllines; CVCL_0405
LIMORE; Mahlavu
Anatomy/cell type resources BTO; BTO_0004471
Chemistry resources ChEMBL-Cells; CHEMBL4295417
ChEMBL-Targets; CHEMBL4296473
PubChem_Cell_line; CVCL_0405
Encyclopedic resources Wikidata; Q54903975
Experimental variables resources EFO; EFO_0022710
Gene expression databases GEO; GSM2551578
Polymorphism and mutation databases Cosmic; 873398
Cosmic; 948064
Cosmic; 979727
Cosmic; 1019317
Cosmic; 2162534
Cosmic; 2321039
IARC_TP53; 2183
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28