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Cellosaurus LbetaT2 (CVCL_0398)

[Text version]
Cell line name LbetaT2
Synonyms L-beta-T2; L beta T2; Lbeta T2; L{beta}T2; Lbetat2; LbT2
Accession CVCL_0398
Resource Identification Initiative To cite this cell line use: LbetaT2 (RRID:CVCL_0398)
Comments Characteristics: Widely used as an in vitro model for the study of gonadotropin gene regulation and GnRH signaling (Millipore=SCC412).
Characteristics: Expresses CGA, GnRH-R and the alpha and beta subunits of LH (PubMed=8770922).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 x BALB/c transgenic.
Hierarchy Children:
CVCL_E0X8 (Ubigene LbetaT2 Foxk2 KO)
Sex of cell Female
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): Millipore=SCC412

Markers:
Mouse STR 1-116,17
Mouse STR 1-219
Mouse STR 2-116
Mouse STR 3-213
Mouse STR 4-220.3,21.3
Mouse STR 5-513,17
Mouse STR 6-419,20
Mouse STR 6-712
Mouse STR 7-126.2
Mouse STR 8-116
Mouse STR 11-216,18
Mouse STR 12-116,17
Mouse STR 13-116.2
Mouse STR 15-322.3
Mouse STR 17-215
Mouse STR 18-316,17
Mouse STR 19-212
Mouse STR X-125

Run an STR similarity search on this cell line
Publications

PubMed=8770922; DOI=10.1210/endo.137.7.8770922
Paul Thomas, Pamela L. Mellon, Judith L. Turgeon, Dennis W. Waring;
The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion.
Endocrinology 137:2979-2989(1996)

PubMed=8898243; DOI=10.1242/dev.122.10.3319
Elaine T. Alarid, Jolene J. Windle, David B. Whyte, Pamela L. Mellon;
Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice.
Development 122:3319-3329(1996)

PubMed=11356674; DOI=10.1210/endo.142.6.8185
Flavia Pernasetti, Vyacheslav V. Vasilyev, Suzanne B. Rosenberg, Janice S. Bailey, Huey-Jing Huang, William L. Miller, Pamela L. Mellon;
Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model.
Endocrinology 142:2284-2295(2001)

PubMed=15541569; DOI=10.1016/j.mce.2004.07.018
Guck T. Ooi, Neveen Tawadros, Ruth M. Escalona;
Pituitary cell lines and their endocrine applications.
Mol. Cell. Endocrinol. 228:1-21(2004)

PubMed=31020055; DOI=10.1210/js.2019-00064; PMCID=PMC6469952
Frederique Ruf-Zamojski, Yong-Chao Ge, Hanna Pincas, Ji-Dong Shan, Ying-Hui Song, Nika Hines, Kevin Kelley, Cristina Montagna, Pranav Nair, Chirine Toufaily, Daniel J. Bernard ...Show all 15 authors... , Pamela L. Mellon, Venugopalan Nair, Judith L. Turgeon, Stuart C. Sealfon; Show fewer authors
Cytogenetic, genomic, and functional characterization of pituitary gonadotrope cell lines.
J. Endocr. Soc. 3:902-920(2019)

Cross-references
Cell line collections (Providers) Millipore; SCC412
Cell line databases/resources MCCL; MCC:0000292
Lonza; 1263
TOKU-E; 4079
Anatomy/cell type resources BTO; BTO_0004467
Encyclopedic resources Wikidata; Q54902109
Experimental variables resources EFO; EFO_0002070
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number21