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Cellosaurus LA-N-5 (CVCL_0389)

[Text version]
Cell line name LA-N-5
Synonyms LAN-5; Lan-5; LAN5; Lan5; NBLAN5T
Accession CVCL_0389
Resource Identification Initiative To cite this cell line use: LA-N-5 (RRID:CVCL_0389)
Comments Doubling time: ~100 hours (DSMZ=ACC-673).
Omics: Array-based CGH.
Omics: Chromatin accessibility by ATAC-seq.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: On the basis that LA-350 (Cellosaurus=CVCL_AR50) and LA-N-5 are both established by Seeger R.C., that they share identical STR profiles and that LA-350 is said to originate from a patient suffering from neuroblastoma we have annotated them as being autologous cell lines.
Misspelling: LAN-3; Cosmic=920242.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_AR50 ! LA-350
Sex of cell Male
Age at sampling 4M
Category Cancer cell line
STR profile Source(s): COG; DSMZ; RCB

10,11 (DSMZ; RCB)
D16S5399 (DSMZ)
9,12 (COG; RCB)
Penta D11,13
Penta E11,12

Run an STR similarity search on this cell line
Web pages http://www.cccells.org/dl/NB_Data_Sheets/LA-N-5_Cell_Line_Data_Sheet_COGcell_org.pdf

PubMed=6172518; DOI=10.4049/jimmunol.128.2.983
Seeger R.C., Danon Y.L., Rayner S.A., Hoover F.
Definition of a Thy-1 determinant on human neuroblastoma, glioma, sarcoma, and teratoma cells with a monoclonal antibody.
J. Immunol. 128:983-989(1982)

Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

Thiele C.J.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026
Komuro H., Saihara R., Shinya M., Takita J., Kaneko S., Kaneko M., Hayashi Y.
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
J. Pediatr. Surg. 42:2040-2045(2007)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923524; DOI=10.1038/nature07399
Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004
Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N., Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C., Messiaen L.M., Versteeg R., Bernards R.
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Farooqi A.S., Dagg R.A., Choi L.M.R., Shay J.W., Reynolds C.P., Lau L.M.S.
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cell line collections (Providers) DSMZ; ACC-673
ICLC; HTL96022 - Discontinued
NCBI_Iran; C613
RCB; RCB0485
Cell line databases/resources CLO; CLO_0007242
CLO; CLO_0050264
MCCL; MCC:0000284
CLDB; cl3170
CLDB; cl3171
cancercelllines; CVCL_0389
DSMZCellDive; ACC-673
Lonza; 1157
Anatomy/cell type resources BTO; BTO:0000935
Biological sample resources BioSample; SAMN03472329
BioSample; SAMN03473428
Encyclopedic resources Wikidata; Q54901878
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM313804
GEO; GSM333799
GEO; GSM692871
GEO; GSM2371239
GEO; GSM2394369
GEO; GSM4104579
GEO; GSM4104580
GEO; GSM4104628
GEO; GSM4104629
GEO; GSM4105313
GEO; GSM4105314
GEO; GSM4105315
GEO; GSM4105316
GEO; GSM4105317
Polymorphism and mutation databases Cosmic; 801742
Cosmic; 920242
Cosmic; 923828
Cosmic; 930066
Cosmic; 947705
Cosmic; 1037345
Cosmic; 1099142
Cosmic; 1109122
Cosmic; 1153783
Cosmic; 1161992
Cosmic; 1167989
Cosmic; 1212538
Cosmic; 1518068
Cosmic; 1526629
Cosmic; 1890201
Cosmic; 2131580
Cosmic; 2239462
Cosmic; 2301576
Cosmic; 2393636
IARC_TP53; 21459
Progenetix; CVCL_0389
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number35