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Cellosaurus LA-N-5 (CVCL_0389)

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Cell line name LA-N-5
Synonyms LAN-5; Lan-5; LAN5; Lan5; NBLAN5T
Accession CVCL_0389
Resource Identification Initiative To cite this cell line use: LA-N-5 (RRID:CVCL_0389)
Comments Doubling time: ~100 hours (DSMZ=ACC-673).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Miscellaneous: On the basis that LA-350 (Cellosaurus=CVCL_AR50) and LA-N-5 are both established by Seeger R.C., that they share identical STR profiles and that LA-350 is said to originate from a patient suffering from neuroblastoma we have annotated them as being autologous cell lines.
Misspelling: LAN-3; Cosmic=920242.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_AR50 ! LA-350
Sex of cell Male
Age at sampling 4M
Category Cancer cell line
STR profile Source(s): COG; DSMZ=ACC-673; RCB=RCB0485

Markers:
AmelogeninX,Y
CSF1PO10 (COG)
10,11 (DSMZ=ACC-673; RCB=RCB0485)
D2S133819,25
D3S135815,16
D5S81811
D7S82010
D8S117911,13
D13S3179,12
D16S5399 (DSMZ=ACC-673)
9,12 (COG; RCB=RCB0485)
D18S5117,22
D19S43313,15
D21S1129,31
FGA21,27
Penta D11,13
Penta E11,12
TH016,9.3
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-481.html
Provider; CCR; -; https://www.cccells.org/dl/NB_Data_Sheets/LA-N-5_Cell_Line_Data_Sheet_COGcell_org.pdf
Publications

PubMed=6172518; DOI=10.4049/jimmunol.128.2.983
Robert C. Seeger, Yehuda L. Danon, Sylvia A. Rayner, Frank Hoover;
Definition of a Thy-1 determinant on human neuroblastoma, glioma, sarcoma, and teratoma cells with a monoclonal antibody.
J. Immunol. 128:983-989(1982)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026
Hiroaki Komuro, Ryoko Saihara, Miki Shinya, Junko Takita, Setsuko Kaneko, Michio Kaneko, Yasuhide Hayashi;
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
J. Pediatr. Surg. 42:2040-2045(2007)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Michael Holzel, Si-Dong Huang, Jan Koster, Ingrid Ora, Arjan Lakeman, Huib Nicolaas Caron, Wouter Nijkamp, Jing Xie, Tom Callens, Shahab Asgharzadeh, Robert C. Seeger ...Show all 14 authors... , Ludwine M. Messiaen, Rogier Versteeg, Rene Bernards; Show fewer authors
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, Charles Patrick Reynolds, Loretta M.S. Lau;
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

Cross-references
Cell line collections (Providers) DSMZ; ACC-673
ICLC; HTL96022 - Discontinued
NCBI_Iran; C613
RCB; RCB0485
Cell line databases/resources CLO; CLO_0007242
CLO; CLO_0050264
MCCL; MCC:0000284
CLDB; cl3170
CLDB; cl3171
cancercelllines; CVCL_0389
DSMZCellDive; ACC-673
LINCS_LDP; LCL-1987
Lonza; 1157
Anatomy/cell type resources BTO; BTO_0000935
Biological sample resources BioSample; SAMN03472329
BioSample; SAMN03473428
Encyclopedic resources Wikidata; Q54901878
Experimental variables resources EFO; EFO_0022688
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM313804
GEO; GSM333799
GEO; GSM692871
GEO; GSM2371239
GEO; GSM2394369
GEO; GSM4104579
GEO; GSM4104580
GEO; GSM4104628
GEO; GSM4104629
GEO; GSM4105313
GEO; GSM4105314
GEO; GSM4105315
GEO; GSM4105316
GEO; GSM4105317
Polymorphism and mutation databases Cosmic; 801742
Cosmic; 920242
Cosmic; 923828
Cosmic; 930066
Cosmic; 947705
Cosmic; 1037345
Cosmic; 1099142
Cosmic; 1109122
Cosmic; 1153783
Cosmic; 1161992
Cosmic; 1167989
Cosmic; 1212538
Cosmic; 1518068
Cosmic; 1526629
Cosmic; 1890201
Cosmic; 2131580
Cosmic; 2239462
Cosmic; 2301576
Cosmic; 2393636
IARC_TP53; 21459
Progenetix; CVCL_0389
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39