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Cellosaurus J2E (CVCL_0355)

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Cell line name J2E
Synonyms J2E-1
Accession CVCL_0355
Resource Identification Initiative To cite this cell line use: J2E (RRID:CVCL_0355)
Comments Characteristics: Differentiates and synthesizes hemoglobin following exposure to EPO.
Transformant: Recombinant retrovirus J2.
Derived from site: In situ; Embryonic liver; UBERON=UBERON_0002107.
Cell type: Erythroblast; CL=CL_0000765.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: CBA.
Hierarchy Children:
CVCL_5984 (J2E-NR)
Sex of cell Sex unspecified
Age at sampling 12FD
Category Transformed cell line
Publications

PubMed=2847163; DOI=10.1073/pnas.85.22.8506; PMCID=PMC282487
Svend Peter Klinken, Nicos Anthony Nicola, Gregory R. Johnson;
In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.
Proc. Natl. Acad. Sci. U.S.A. 85:8506-8510(1988)

PubMed=1688637
Svend Peter Klinken, Nicos Anthony Nicola;
Evolution of a mutant J2E erythroid cell line which does not respond to erythropoietin.
Leukemia 4:24-28(1990)

PubMed=8631947; DOI=10.1074/jbc.271.7.3453
Peta A. Tilbrook, Thomas Bittorf, Samantha J. Busfield, David Chappell, Svend Peter Klinken;
Disrupted signaling in a mutant J2E cell line that shows enhanced viability, but does not proliferate or differentiate, with erythropoietin.
J. Biol. Chem. 271:3453-3459(1996)

Cross-references
Cell line databases/resources MCCL; MCC:0000249
Encyclopedic resources Wikidata; Q54898464
Experimental variables resources EFO; EFO_0022772
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number11