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Cellosaurus HSC-T6 (CVCL_0315)

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Cell line name HSC-T6
Synonyms HSCT6
Accession CVCL_0315
Resource Identification Initiative To cite this cell line use: HSC-T6 (RRID:CVCL_0315)
Comments Doubling time: 10 hours (PubMed=26300973).
Karyotypic information: 43,XX,der(1),+4,+7,-12,+mar (PubMed=35681478).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptomics; RNAseq.
Caution: Was originally (PubMed=10828080) reported to be established from a male rat, but was later shown (PubMed=35681478) to have a female karyotype.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatic stellate cell; CL=CL_0000632.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley; RS=RS_0000681.
Hierarchy Children:
CVCL_F4RK (HyCyte HSC-T6 stable cell line for rStat3 overexpression)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=10828080; DOI=10.1016/S0022-2275(20)32030-7
Silke Vogel, Roseann Piantedosi, Jorge Frank, Avraham Lalazar, Don C. Rockey, Scott Laurence Friedman, William S. Blaner;
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.
J. Lipid Res. 41:882-893(2000)

PubMed=17760834; DOI=10.1111/j.1582-4934.2007.00060.x; PMCID=PMC3823251
Jens Herrmann, Axel M. Gressner, Ralf Weiskirchen;
Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
J. Cell. Mol. Med. 11:704-722(2007)

PubMed=26300973; DOI=10.1186/s13069-015-0032-y; PMCID=PMC4546255
Louise Catherine Stone, Lorna Susan Thorne, Christopher John Weston, Mark Graham, Nikolas John Hodges;
Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling.
Fibrogenesis Tissue Repair 8:15.1-15.15(2015)

PubMed=35681478; DOI=10.3390/cells11111783; PMCID=PMC9179542
Indrajit Nanda, Claus Steinlein, Thomas Haaf, Eva Miriam Buhl, Dominik G. Grimm, Scott Laurence Friedman, Steffen K. Meurer, Sarah K. Schroder, Ralf Weiskirchen;
Genetic characterization of rat hepatic stellate cell line HSC-T6 for in vitro cell line authentication.
Cells 11:1783.1-1783.21(2022)

Cross-references
Cell line collections (Providers) CLS; 305199
KCB; KCB 200703YJ
Millipore; SCC069
Cell line databases/resources MCCL; MCC:0000208
Anatomy/cell type resources BTO; BTO_0003520
Chemistry resources ChEMBL-Cells; CHEMBL4651377
PubChem_Cell_line; CVCL_0315
Encyclopedic resources Wikidata; Q54896418
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number20