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Cellosaurus HMEC-1 (CVCL_0307)

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Cell line name HMEC-1
Synonyms Hmec-1; HMEC1; CDC/EU.HMEC-1; Human Microvascular Endothelial Cell line-1
Accession CVCL_0307
Resource Identification Initiative To cite this cell line use: HMEC-1 (RRID:CVCL_0307)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10636.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVT).
Derived from site: In situ; Foreskin, skin, dermis; UBERON=UBERON_0001471+UBERON_0002067.
Cell type: Endothelial cell; CL=CL_0000115.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling <1M
Category Transformed cell line
STR profile Source(s): ATCC=CRL-3243

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81812
D7S8208,10
D13S31711,12
D16S53911,12
TH017
TPOX8,11
vWA15,17

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Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-159.html
Publications

Patent=WO1992017569A1
Edwin W. Ades, Thomas J. Lawley, Francisco J. Candal;
Immortalization of endothelial cells.
Patent number WO1992017569A1, 15-Oct-1992

PubMed=1361507; DOI=10.1111/1523-1747.ep12613748
Edwin W. Ades, Francisco J. Candal, Robert A. Swerlick, Velma G. George, Susan Summers, Daniel C. Bosse, Thomas J. Lawley;
HMEC-1: establishment of an immortalized human microvascular endothelial cell line.
J. Invest. Dermatol. 99:683-690(1992)

PubMed=12453433; DOI=10.1006/mvre.2002.2434
Ronald E. Unger, Vera Krump-Konvalinkova, Kirsten Peters, Charles James Kirkpatrick;
In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R.
Microvasc. Res. 64:384-397(2002)

Cross-references
Cell line collections (Providers) ATCC; CRL-3243
CLS; 304064
Cell line databases/resources MCCL; MCC:0000200
Lonza; 736
Anatomy/cell type resources BTO; BTO_0002828
Chemistry resources ChEMBL-Cells; CHEMBL4295409
ChEMBL-Targets; CHEMBL4296433
PubChem_Cell_line; CVCL_0307
Encyclopedic resources Wikidata; Q54889921
Experimental variables resources EFO; EFO_0005383
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number26