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Cellosaurus GEO (CVCL_0271)

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Cell line name GEO
Synonyms Geo; HCT-GEO; HCT GEO
Accession CVCL_0271
Resource Identification Initiative To cite this cell line use: GEO (RRID:CVCL_0271)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Cys344fs*110 (c.1030delT); Zygosity=Homozygous (Cosmic-CLP=2164691; DepMap=ACH-002394).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu1536Ter (c.4606G>T); ClinVar=VCV001050551; Zygosity=Homozygous (Cosmic-CLP=2164691; DepMap=ACH-002394).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (PubMed=20570890; Cosmic-CLP=2164691; DepMap=ACH-002394).
Genome ancestry Source: PubMed=30894373

Origin% genome
African61.65
Native American2.66
East Asian, North1.33
East Asian, South0
South Asian0
European, North19.42
European, South14.94
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
D5S81812
D7S82010,11,11.1
D13S3178,12
D16S53912
D21S1129
TH018
TPOX8
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=7329817
Michael G. Brattain, Diane E. Brattain, W. David Fine, F. Mahnaz Khaled, Michael E. Marks, Pamela M. Kimball, Laurie A. Arcolano, Bernice H. Danbury;
Initiation and characterization of cultures of human colonic carcinoma with different biological characteristics utilizing feeder layers of confluent fibroblasts.
Oncodev. Biol. Med. 2:355-366(1981)

PubMed=6578361; DOI=10.1093/jnci/71.4.663
Michael E. Marks, Bernice H. Danbury, Charles A. Miller 3rd, Michael G. Brattain;
Cell surface proteins and glycoproteins from biologically different human colon carcinoma cell lines.
J. Natl. Cancer Inst. 71:663-671(1983)

PubMed=2835152
Douglas Boyd, Germaine Florent, Paul Kim, Michael G. Brattain;
Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines.
Cancer Res. 48:3112-3116(1988)

PubMed=3349466
Isabelle Chantret, Alain Barbat, Elisabeth Dussaulx, Michael G. Brattain, Alain Zweibaum;
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=7761852; DOI=10.1126/science.7761852
Sanford David Markowitz, Jing Wang, Lois Lemmermann Myeroff, Ramon Parsons, Lu-Zhe Sun, James D. Lutterbaugh, Robert S. Fan, Elizabeth Zborowska, Kenneth Wayne Kinzler, Bert Vogelstein, Michael G. Brattain, James K.V. Willson;
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=17363507; DOI=10.1158/1535-7163.MCT-06-0555
Jing Wang, Karen K. Kuropatwinski, Jennie Hauser, Michael R. Rossi, Yun-Fei Zhou, Alexis Conway, Julie L.C. Kan, Neil W. Gibson, James K.V. Willson, John Kenneth Cowell, Michael G. Brattain;
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.
Mol. Cancer Ther. 6:1143-1150(2007)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514
Manickam Janakiraman, Efsevia Vakiani, Zhao-Shi Zeng, Christine A. Pratilas, Barry Stephen Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Marques Ricarte Filho, Yogindra Persaud ...Show all 21 authors... , Douglas A. Levine, James Alexander Fagin, Suresh C. Jhanwar, John M. Mariadason, Alex Lash, Marc Ladanyi, Leonard B. Saltz, Adriana Heguy, Philip B. Paty, David B. Solit; Show fewer authors
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010; PMCID=PMC5583477
Theodoros I. Roumeliotis, Steven P. Williams, Emanuel Goncalves, Clara Alsinet, Martin Del Castillo Velasco-Herrera, Nanne Aben, Fatemeh Zamanzad Ghavidel, Magali Michaut, Michael Schubert, Stacey Price, James C. Wright ...Show all 24 authors... , Lu Yu, Mi Yang, Rodrigo Dienstmann, Justin H. Guinney, Pedro Beltrao, Alvis Brazma, Mercedes Pardo, Oliver Stegle, David J. Adams, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Jyoti S. Choudhary; Show fewer authors
Genomic determinants of protein abundance variation in colorectal cancer cells.
Cell Rep. 20:2201-2214(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources MCCL; MCC:0000162
cancercelllines; CVCL_0271
Cell_Model_Passport; SIDM00068
ColonAtlas; GEO
Cosmic-CLP; 2164691
DepMap; ACH-002394
Anatomy/cell type resources BTO; BTO_0002892
Chemistry resources GDSC; 2164691
PharmacoDB; Geo_403_2019
Encyclopedic resources Wikidata; Q54835723
Gene expression databases GEO; GSM1448176
Polymorphism and mutation databases Cosmic; 738930
Cosmic; 889529
Cosmic; 1131685
Cosmic; 1479567
Cosmic; 1708407
Proteomic databases PRIDE; PXD005235
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31