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Cellosaurus COLO 320DM (CVCL_0219)

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Cell line name COLO 320DM
Synonyms COLO-320DM; COLO_320DM; COLO-320-DM; COLO #320DM; COLO320/DM; COLO320-DM; COLO320DM; Colo320DM; COLO320 DM; COLO 320 DM; COLO 320 (DM); Colorado 320 Double Minutes
Accession CVCL_0219
Resource Identification Initiative To cite this cell line use: COLO 320DM (RRID:CVCL_0219)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (PubMed=24755471; PubMed=25926053).
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: COLD-320-DM; Cosmic=1466812.
Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*14:02,39:10
HLA-CC*08:02,08:02
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1989 (COLO 320)
Children:
CVCL_XD07 (COLO 320DM-EGFP)CVCL_XD08 (COLO 320DM-RFP)CVCL_A6UJ (COLO 320DM#3)
CVCL_A6UK (COLO 320DM#3 SIRT1 KO cl.1)CVCL_A6UL (COLO 320DM#3 SIRT1 KO cl.2)CVCL_A6UM (COLO 320DM#3 SIRT1 KO cl.3)
CVCL_A6UN (COLO 320DM#3 SIRT1 KO cl.4)CVCL_A6UP (COLO 320DM#3 SIRT1 KO cl.5)CVCL_A6UQ (COLO 320DM#3 SIRT1 KO cl.6)
CVCL_1990 (COLO 320DMF)CVCL_0220 (COLO 320HSR)CVCL_F641 (COLO 587)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-220; CCRID; CLS=300153; ECACC=87061205; JCRB=JCRB0225; KCLB=10220; PubMed=25877200; PubMed=25926053

Markers:
AmelogeninX
CSF1PO11 (ATCC=CCL-220; CCRID; CLS=300153; JCRB=JCRB0225; KCLB=10220; PubMed=25877200; PubMed=25926053)
11,12 (ECACC=87061205)
D2S133818,25
D3S135817
D5S81812
D7S8209,12
D8S117913
D13S31711
D16S53911,12
D18S5115
D19S43315,16.2 (ATCC=CCL-220)
16.2 (CCRID)
D21S1131,33.2 (ATCC=CCL-220; PubMed=25926053)
33.2 (CCRID; CLS=300153; PubMed=25877200)
FGA20
Penta D9,12
Penta E11 (CLS=300153; PubMed=25877200)
11,13 (ATCC=CCL-220)
TH018,9 (ECACC=87061205)
9 (ATCC=CCL-220; CCRID; CLS=300153; JCRB=JCRB0225; KCLB=10220; PubMed=25877200; PubMed=25926053)
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=498117
Laurie A. Quinn, George Eugene Moore, Robert T. Morgan, Linda K. Woods;
Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.
Cancer Res. 39:4914-4924(1979)

PubMed=3164477; DOI=10.1073/pnas.85.13.4804; PMCID=PMC280524
Daniel D. Von Hoff, Donald R. Needham-VanDevanter, Jennifer Yucel, Bradford E. Windle, Geoffrey Myles Wahl;
Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.
Proc. Natl. Acad. Sci. U.S.A. 85:4804-4808(1988)

PubMed=7874267; DOI=10.1007/BF02349278
Shigeo Ikuta, Fumio Itoh, Yuji Hinoda, Minoru Toyota, Yusuke Makiguchi, Kohzoh Imai, Akira Yachi;
Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
J. Gastroenterol. 29:727-732(1994)

PubMed=7651727
William Vasilios Kastrinakis, Nirasha Ramchurren, Karen M. Rieger, Donald T. Hess, Massimo Loda, Glenn Steele, Ian C. Summerhayes;
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350
Turid Knutsen, Hesed Maria Padilla-Nash, Danny Wangsa, Linda Barenboim-Stapleton, Jordi Camps, Nicole E. McNeil, Michael J. Difilippantonio, Thomas Ried;
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Genes Chromosomes Cancer 49:204-223(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28179481; DOI=10.1158/1535-7163.MCT-16-0578
Noritaka Tanaka, Tetsuo Mashima, Anna Mizutani, Ayana Sato, Aki Aoyama, Bo Gong, Haruka Yoshida, Yukiko Muramatsu, Kento Nakata, Masaaki Matsuura, Ryohei Katayama ...Show all 15 authors... , Satoshi Nagayama, Naoya Fujita, Yoshikazu Sugimoto, Hiroyuki Seimiya; Show fewer authors
APC mutations as a potential biomarker for sensitivity to tankyrase inhibitors in colorectal cancer.
Mol. Cancer Ther. 16:752-762(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections (Providers) ATCC; CCL-220
BCRC; 60108
CCTCC; GDC0042
CLS; 300153
ECACC; 87061205
JCRB; JCRB0225
KCB; KCB 200694YJ
KCLB; 10220
Cell line databases/resources CLO; CLO_0002546
MCCL; MCC:0000108
CLDB; cl827
cancercelllines; CVCL_0219
CCRID; 1101HUM-PUMC000133
CCRID; 3101HUMTCHu208
ColonAtlas; COLO320DM
LINCS_LDP; LCL-1197
SKY/M-FISH/CGH; 5014
TOKU-E; 985
Biological sample resources BioSample; SAMN03471612
Chemistry resources ChEMBL-Cells; CHEMBL3307647
ChEMBL-Targets; CHEMBL614562
PharmacoDB; COLO320DM_216_2019
PubChem_Cell_line; CVCL_0219
Encyclopedic resources Wikidata; Q54814089
Experimental variables resources EFO; EFO_0002136
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206461
GEO; GSM274777
GEO; GSM513909
GEO; GSM514187
GEO; GSM739989
GEO; GSM739990
GEO; GSM739991
GEO; GSM740012
GEO; GSM784007
GEO; GSM827245
GEO; GSM1346834
GEO; GSM1374454
GEO; GSM1374455
GEO; GSM1448173
Polymorphism and mutation databases Cosmic; 808509
Cosmic; 1043807
Cosmic; 1223136
Cosmic; 1310932
Cosmic; 1312298
Cosmic; 1374635
Cosmic; 1466812
Cosmic; 2301969
Cosmic; 2664052
Cosmic; 2668253
Cosmic; 2760069
Cosmic; 2811047
IARC_TP53; 4553
Progenetix; CVCL_0219
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number40