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Cellosaurus CMK-11-5 (CVCL_0217)

[Text version]
Cell line name CMK-11-5
Synonyms CMK 11-5; CMK11-5; CMK115
Accession CVCL_0217
Resource Identification Initiative To cite this cell line use: CMK-11-5 (RRID:CVCL_0217)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: ~2 days (Note=Lot 12122008), ~34 hours (Note=Lot 12082016) (JCRB=IFO50430).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.58
Native American0
East Asian, North95.47
East Asian, South0
South Asian0
European, North0
European, South3.94
Disease Down syndrome (NCIt: C2993)
Myeloid leukemia associated with Down syndrome (NCIt: C43223)
Down syndrome (ORDO: Orphanet_870)
Acute megakaryoblastic leukemia in Down syndrome (ORDO: Orphanet_99887)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2804 (CMK-86)
Sex of cell Male
Age at sampling 10M
Category Cancer cell line
STR profile Source(s): JCRB=IFO50430

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81811,12
D7S82011,12
D13S31711
D16S5399,11
TH017
TPOX9,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=1991165; DOI=10.1182/blood.V77.3.481.481
Mamoru Sakaguchi, Takeyuki Sato, Jerome Elliot Groopman;
Human immunodeficiency virus infection of megakaryocytic cells.
Blood 77:481-485(1991)

PubMed=1391807
Takahiro Nagano, Shigetoshi Ohga, Yuji Kishimoto, Takashi Kimura, Kojiro Yasunaga, Masashi Adachi, Ryukichi Ryo, Takeyuki Sato;
Ultrastructural analysis of platelet-like particles from a human megakaryocytic leukemia cell line (CMK 11-5).
Int. J. Hematol. 56:67-78(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16778363; DOI=10.1620/tjem.209.169
Rika Kanezaki, Tsutomu Toki, Gang Xu, Ramswamy Narayanan, Etsuro Ito;
Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5.
Tohoku J. Exp. Med. 209:169-180(2006)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32180119; DOI=10.1007/s12185-020-02853-6
Hiroshi Saito, Morisada Hayakawa, Nobuhiko Kamoshita, Atsushi Yasumoto, Katsue Suzuki-Inoue, Yutaka Yatomi, Tsukasa Ohmori;
Establishment of a megakaryoblastic cell line for conventional assessment of platelet calcium signaling.
Int. J. Hematol. 111:786-794(2020)

Cross-references
Cell line collections (Providers) JCRB; IFO50430
Cell line databases/resources MCCL; MCC:0000106
cancercelllines; CVCL_0217
Cell_Model_Passport; SIDM01235
DepMap; ACH-001036
Biological sample resources BioSample; SAMN10987844
Chemistry resources PharmacoDB; CMK115_211_2019
Encyclopedic resources Wikidata; Q54813771
Gene expression databases GEO; GSM886937
GEO; GSM888003
Polymorphism and mutation databases IARC_TP53; 28399
Progenetix; CVCL_0217
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28