Cellosaurus cell line AlphaT3-1 (CVCL

Cellosaurus AlphaT3-1 (CVCL_0149)

Cross-references
Cell line name	AlphaT3-1
Synonyms	AlphaT31; alphaT3-1; alpha T3-1; alpha-T3-1; aT3-1
Accession	CVCL_0149
Resource Identification Initiative	To cite this cell line use: AlphaT3-1 (RRID:CVCL_0149)
Comments	Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/6 x BALB/c transgenic.
Sex of cell	Male
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=1704103; DOI=10.1210/mend-4-4-597 Jolene J. Windle, Richard I. Weiner, Pamela L. Mellon; Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol. Endocrinol. 4:597-603(1990) PubMed=8898243; DOI=10.1242/dev.122.10.3319 Elaine T. Alarid, Jolene J. Windle, David B. Whyte, Pamela L. Mellon; Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development 122:3319-3329(1996) PubMed=15541569; DOI=10.1016/j.mce.2004.07.018 Guck T. Ooi, Neveen Tawadros, Ruth M. Escalona; Pituitary cell lines and their endocrine applications. Mol. Cell. Endocrinol. 228:1-21(2004) PubMed=31020055; DOI=10.1210/js.2019-00064; PMCID=PMC6469952 Frederique Ruf-Zamojski, Yong-Chao Ge, Hanna Pincas, Ji-Dong Shan, Ying-Hui Song, Nika Hines, Kevin Kelley, Cristina Montagna, Pranav Nair, Chirine Toufaily, Daniel J. Bernard ...Show all 15 authors... , Pamela L. Mellon, Venugopalan Nair, Judith L. Turgeon, Stuart C. Sealfon; Show fewer authors Cytogenetic, genomic, and functional characterization of pituitary gonadotrope cell lines. J. Endocr. Soc. 3:902-920(2019)
Cell line databases/resources	MCCL; MCC:0000042
Anatomy/cell type resources	BTO; BTO_0003566
Encyclopedic resources	Wikidata; Q54749261
Experimental variables resources	EFO; EFO_0022819
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	17