Cellosaurus logo
expasy logo

Cellosaurus JY (CVCL_0108)

[Text version]
Cell line name JY
Synonyms JY-S
Accession CVCL_0108
Resource Identification Initiative To cite this cell line use: JY (RRID:CVCL_0108)
Comments Part of: 12th International Histocompatibility Workshop (12IHW) cell line panel.
Population: Caucasian; Amish.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=22238296).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; MHC region sequencing.
Omics: Proteomics; HLA class I peptidome.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,02:01
HLA-BB*07:02,07:02
HLA-CC*07:02,07:02
Class II
HLA-DQDQA1*03:02,01:03
DQB1*06:11,03:02
HLA-DRDRB1*04:04,13:01

Source: IPD-IMGT/HLA=10882
Class I
HLA-AA*02:01:01:01
HLA-BB*07:02:01:01
HLA-CC*07:02:01:01,07:02:01:03
Class II
HLA-DPDPA1*01:03
DPB1*02:01:02:01,04:01
HLA-DQDQA1*01:03,03:01:01
DQB1*03:02;06:03
HLA-DRDRA*01:01:01:01,01:02:01
DRB1*04:04,13:01
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3D6 (JY/R7hyg)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/j/cell-lines-detail-50.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/JY_cell_line
Publications

PubMed=6294325; DOI=10.1128/JVI.44.3.1088-1091.1982; PMCID=PMC256372
James Skare, Clark Edson, John Farley, Jack Leonard Strominger;
The B95-8 isolate of Epstein-Barr virus arose from an isolate with a standard genome.
J. Virol. 44:1088-1091(1982)

PubMed=6417007; DOI=10.1007/BF00364387
M. Rosa Bono, Jack Leonard Strominger;
NH2-terminal sequence of the alpha and beta chains of human DC-1 antigen isolated from the JY cell line. Homology with murine I-A molecules.
Immunogenetics 18:453-459(1983)

PubMed=7523570; DOI=10.1084/jem.180.4.1283; PMCID=PMC2191672
Theodore J. Tsomides, Anna Aldovini, R. Paul Johnson, Bruce D. Walker, Richard Allen Young, Herman Nathaniel Eisen;
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
J. Exp. Med. 180:1283-1293(1994)

PubMed=22238296; DOI=10.1128/JVI.06717-11; PMCID=PMC3302299
Zhen Lin, Adriane Puetter, Joseph Coco, Guo-Rong Xu, Michael J. Strong, Xia Wang, Claire Fewell, Melody Baddoo, Christopher Taylor, Erik K. Flemington;
Detection of murine leukemia virus in the Epstein-Barr virus-positive human B-cell line JY, using a computational RNA-Seq-based exogenous agent detection pipeline, PARSES.
J. Virol. 86:2970-2977(2012)

PubMed=23619976; DOI=10.1007/s00262-013-1412-z; PMCID=PMC11028802
Frank Neumann, Dominic Kaddu-Mulindwa, Thomas Widmann, Klaus-Dieter Preuss, Gerhard Held, Carsten Zwick, Klaus Roemer, Michael Pfreundschuh, Boris Kubuschok;
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
Cancer Immunol. Immunother. 62:1211-1222(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25576301; DOI=10.1074/mcp.M114.042812; PMCID=PMC4349985
Michal Bassani-Sternberg, Sune Pletscher-Frankild, Lars Juhl Jensen, Matthias Mann;
Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.
Mol. Cell. Proteomics 14:658-673(2015)

PubMed=28360230; DOI=10.1101/gr.213538.116; PMCID=PMC5411776
Paul J. Norman, Steven J. Norberg, Lisbeth A. Guethlein, Neda Nemat-Gorgani, Thomas Royce, Emily E. Wroblewski, Tamsen Dunn, Tobias Mann, Claudia Alicata, Jill A. Hollenbach, Wei-Hua Chang ...Show all 16 authors... , Melissa Shults Won, Kevin L. Gunderson, Laurent Abi-Rached, Mostafa Ronaghi, Peter Parham; Show fewer authors
Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Genome Res. 27:813-823(2017)

PubMed=29242379; DOI=10.1074/mcp.TIR117.000383; PMCID=PMC5836376
Chloe Chong, Fabio Marino, HuiSong Pak, Julien Racle, Roy Thomas Daniel, Markus Muller, David Gfeller, George Coukos, Michal Bassani-Sternberg;
High-throughput and sensitive immunopeptidomics platform reveals profound interferon gamma-mediated remodeling of the human leukocyte antigen (HLA) ligandome.
Mol. Cell. Proteomics 17:533-548(2018)

PubMed=30844424; DOI=10.1016/j.humimm.2019.03.001; PMCID=PMC6599558
Lisa E. Creary, Sandra G. Guerra, Winnie Chong, Colin J. Brown, Thomas R. Turner, James Robinson, Will P. Bultitude, Neema P. Mayor, Steven G.E. Marsh, Katsuyuki Saito, Kevin Lam ...Show all 41 authors... , Jamie L. Duke, Timothy L. Mosbruger, Deborah Ferriola, Dimitrios S. Monos, Amanda Willis, Medhat Askar, Gottfried F. Fischer, Chee Loong Saw, Jiannis Ragoussis, Martin Petrek, Carles Serra-Pages, Manel Juan Otero, Catherine Stavropoulos-Giokas, Amalia Dinou, Reem Ameen, Salem Al Shemmari, Eric Spierings, Ketevan Gendzekhadze, Gerald P. Morris, Qiu-Heng Zhang, Zahra Kashi, Susan Hsu, Sridevi Gangavarapu, Kalyan C. Mallempati, Fumiko Yamamoto, Kazutoyo Osoegawa, Tamara Vayntrub, Chia-Jung Chang, John A. Hansen, Marcelo A. Fernandez-Vina; Show fewer authors
Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.
Hum. Immunol. 80:449-460(2019)

PubMed=34925382; DOI=10.3389/fimmu.2021.796584; PMCID=PMC8671986
Soumya Mukherjee, Alvaro Sanchez-Bernabeu, Laura C. Demmers, Wei Wu, Albert J.R. Heck;
The HLA ligandome comprises a limited repertoire of O-GlcNAcylated antigens preferentially associated with HLA-B*07:02.
Front. Immunol. 12:796584.1-796584.10(2021)

Cross-references
Cell line collections (Providers) ECACC; 94022533
Cell line databases/resources CLO; CLO_0037202
dbMHC; 48917
IHW; IHW09287
IPD-IMGT/HLA; 10882
Anatomy/cell type resources BTO; BTO_0003044
Chemistry resources ChEMBL-Cells; CHEMBL3308061
ChEMBL-Targets; CHEMBL613833
PubChem_Cell_line; CVCL_0108
Encyclopedic resources Wikidata; Q6109290
Proteomic databases PRIDE; PXD000394
PRIDE; PXD001872
PRIDE; PXD006939
PRIDE; PXD028633
PRIDE; PXD028874
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30