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Cellosaurus JY (CVCL_0108)

[Text version]
Cell line name JY
Synonyms JY-S
Accession CVCL_0108
Resource Identification Initiative To cite this cell line use: JY (RRID:CVCL_0108)
Comments Part of: 12th International Histocompatibility Workshop (12IHW) cell line panel.
Population: Caucasian; Amish.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=22238296).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: HLA class I peptidome analysis by proteomics.
Omics: MHC region genome.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
HLA typing Source: PubMed=25960936
Class I
Class II

Source: IPD-IMGT/HLA=10882
Class I
Class II
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
Web pages https://en.wikipedia.org/wiki/JY_cell_line

PubMed=6294325; DOI=10.1128/JVI.44.3.1088-1091.1982
Skare J., Edson C., Farley J., Strominger J.L.
The B95-8 isolate of Epstein-Barr virus arose from an isolate with a standard genome.
J. Virol. 44:1088-1091(1982)

PubMed=6417007; DOI=10.1007/BF00364387
Bono M.R., Strominger J.L.
NH2-terminal sequence of the alpha and beta chains of human DC-1 antigen isolated from the JY cell line. Homology with murine I-A molecules.
Immunogenetics 18:453-459(1983)

PubMed=22238296; DOI=10.1128/JVI.06717-11
Lin Z., Puetter A., Coco J., Xu G.-R., Strong M.J., Wang X., Fewell C., Baddoo M., Taylor C., Flemington E.K.
Detection of murine leukemia virus in the Epstein-Barr virus-positive human B-cell line JY, using a computational RNA-Seq-based exogenous agent detection pipeline, PARSES.
J. Virol. 86:2970-2977(2012)

PubMed=23619976; DOI=10.1007/s00262-013-1412-z
Neumann F., Kaddu-Mulindwa D., Widmann T., Preuss K.-D., Held G., Zwick C., Roemer K., Pfreundschuh M., Kubuschok B.
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
Cancer Immunol. Immunother. 62:1211-1222(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25576301; DOI=10.1074/mcp.M114.042812
Bassani-Sternberg M., Pletscher-Frankild S., Jensen L.J., Mann M.
Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.
Mol. Cell. Proteomics 14:658-673(2015)

PubMed=28360230; DOI=10.1101/gr.213538.116
Norman P.J., Norberg S.J., Guethlein L.A., Nemat-Gorgani N., Royce T., Wroblewski E.E., Dunn T., Mann T., Alicata C., Hollenbach J.A., Chang W.-H., Shults Won M., Gunderson K.L., Abi-Rached L., Ronaghi M., Parham P.
Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Genome Res. 27:813-823(2017)

PubMed=29242379; DOI=10.1074/mcp.TIR117.000383
Chong C., Marino F., Pak H., Racle J., Daniel R.T., Muller M., Gfeller D., Coukos G., Bassani-Sternberg M.
High-throughput and sensitive immunopeptidomics platform reveals profound interferon gamma-mediated remodeling of the human leukocyte antigen (HLA) ligandome.
Mol. Cell. Proteomics 17:533-548(2018)

PubMed=30844424; DOI=10.1016/j.humimm.2019.03.001
Creary L.E., Guerra S.G., Chong W., Brown C.J., Turner T.R., Robinson J., Bultitude W.P., Mayor N.P., Marsh S.G.E., Saito K., Lam K., Duke J.L., Mosbruger T.L., Ferriola D., Monos D.S., Willis A., Askar M., Fischer G.F., Saw C.L., Ragoussis J., Petrek M., Serra-Pages C., Juan Otero M., Stavropoulos-Giokas C., Dinou A., Ameen R., Al Shemmari S., Spierings E., Gendzekhadze K., Morris G.P., Zhang Q.-H., Kashi Z., Hsu S., Gangavarapu S., Mallempati K.C., Yamamoto F., Osoegawa K., Vayntrub T., Chang C.-J., Hansen J.A., Fernandez-Vina M.A.
Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.
Hum. Immunol. 80:449-460(2019)

PubMed=34925382; DOI=10.3389/fimmu.2021.796584
Mukherjee S., Sanchez-Bernabeu A., Demmers L.C., Wu W., Heck A.J.R.
The HLA ligandome comprises a limited repertoire of O-GlcNAcylated antigens preferentially associated with HLA-B*07:02.
Front. Immunol. 12:796584.1-796584.10(2021)

Cell line collections (Providers) ECACC; 94022533
Cell line databases/resources CLO; CLO_0037202
dbMHC; 48917
IHW; IHW09287
Anatomy/cell type resources BTO; BTO:0003044
Chemistry resources ChEMBL-Cells; CHEMBL3308061
ChEMBL-Targets; CHEMBL613833
PubChem_Cell_line; CVCL_0108
Encyclopedic resources Wikidata; Q6109290
Proteomic databases PRIDE; PXD000394
PRIDE; PXD001872
PRIDE; PXD006939
PRIDE; PXD028633
PRIDE; PXD028874
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27