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Cellosaurus HTh83 (CVCL_0046)

[Text version]
Cell line name HTh83
Synonyms Hth83; HTH83; HTh 83; HTh-83; hth83; U-Hth83
Accession CVCL_0046
Resource Identification Initiative To cite this cell line use: HTh83 (RRID:CVCL_0046)
Comments Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Gly456_Gly457insGly (c.1368_1369insGGA); Zygosity=Hemizygous (PubMed=30737244).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000160364; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (PubMed=30737244).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=17465858; PubMed=21868764; PubMed=25365311; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO11
D3S135817
D5S81812
D7S82012
D8S117913,17
D13S31711,13
D16S53911,12
D18S5112,14
D21S1128,32.2
FGA23
TH016,9
TPOX8
vWA16,19 (PubMed=17465858; PubMed=25365311; PubMed=30737244)
19 (PubMed=21868764)

Run an STR similarity search on this cell line
Web pages Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Publications

PubMed=10918212; DOI=10.1002/1096-9896(2000)9999:9999<::AID-PATH643>3.0.CO;2-W
Therese Dahlman, Ellen Lammerts, Majstin Wik, Daniel Bergstrom, Lars Grimelius, Kerstin Westermark, Kristofer Rubin, Nils-Erik Heldin;
Fibrosis in undifferentiated (anaplastic) thyroid carcinomas: evidence for a dual action of tumour cells in collagen type I synthesis.
J. Pathol. 191:376-386(2000)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=17465858; DOI=10.1089/thy.2006.0246
Jia-Jing Lee, Theodoros Foukakis, Jamileh Hashemi, Lars Grimelius, Nils-Erik Heldin, Goran Wallin, Christina Rudduck, Weng-Onn Lui, Anders Hoog, Catharina Larsson;
Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models.
Thyroid 17:289-301(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Inigo Landa, Ian Ganly, Timothy A. Chan, Norisato Mitsutake, Michiko Matsuse, Tihana Ibrahimpasic, Ronald A. Ghossein, James Alexander Fagin;
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25365311; DOI=10.1210/jc.2014-2359; PMCID=PMC4318896
Manoj Garg, Ryoko Okamoto, Yasunobu Nagata, Deepika Kanojia, Subhashree Venkatesan, Mayakonda Thippeswamy Anand, Glenn D. Braunstein, Jonathan William Said, Ngan B. Doan, Quoc Ho, Tadayuki Akagi ...Show all 18 authors... , Sigal Gery, Li-Zhen Liu, Kar-Tong Tan, Wee Joo Chang, Henry He Yang, Seishi Ogawa, Harold Phillip Koeffler; Show fewer authors
Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft.
J. Clin. Endocrinol. Metab. 100:725-735(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0046
CCRID; 3101HUMSCSP548
Anatomy/cell type resources BTO; BTO_0005148
Encyclopedic resources Wikidata; Q54896658
Polymorphism and mutation databases Cosmic; 1068624
Cosmic; 1152120
Cosmic; 1239973
Cosmic; 2054092
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27