Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > ZR-75-1

ZR-75-1   [Cellosaurus entry CVCL_0588]

Breast Carcinoma Cell Line

Description A highly rearranged, near triploid cell line, held at the ATCC cell line, obtained from the ECACC.
Notable Features Translocations involve chromosomes 1, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17 and 22. One marker is duplicate and another triplicate. Deletions were detected on chromsomes 1, 6 and 19, and isochromsomes formed from 16 (p and q) and 20. An HSR is present on chromosome 1.
Representative SKY Karyotype
72(51-75).1x2, der(1)t(1;12)(?;q14), del(1)(p?)hsr(1)?, 2x3, 3x3, 4x3, 5x3, 6x1, del(6)(q?)x2, 7x3, der(22)t(7;22)x3, 8x3, der(8)t(8;11)(p12;?), 9x3, 10x3, der(11)t(11;17)x2, 12x3, der(?)t(12;16), der(?)t(1;12), 13x2, 14x2, der(14)t(13;14), 15x2, der(15)t(10;15), der(15)t(1;15), 16x1, i(16)(q), i(16)(p), 17x2, der(?)t(6;17), 18x3, 19x2, del(19)(p?), 20x2, i(20)(q), 21x2, 22x2, der(22)t(15;22)*, Xx3 cp[10]
CGH results  




Breast Cell Lines