Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > SK-BR-3

SK-BR-3   [Cellosaurus entry CVCL_0033]

Breast Carcinoma Cell Line

Description A highly rearranged, near triploid cell line, derived by Fogh and Trempe (1975), obtained from Dr Mike O'Hare.
Notable Features Translocations involve all chromosomes, except 11 and 18. Five markers have been duplicated. Deletions were detected on chromosomes 1, 3, 5, 10 (duplicated), 15 and 18, and an isochromsome 1 is present.
Representative SKY Karyotype
79(68-79).1x1, i(1)(q), der(1?)t(1;4), der(1)t(1;5), der(1)t(1;10), der(1)t(1;5), del(1)?, 2x2, der(?)t(2;6;4), der(2)t(2;6)x2, 3x2, del(3), 4x1, der(?)t(4;14), 5x2, der(?)t(5;19;4;8), del(5), 6x2, 7x7, 8x1, der(8?)t(13;3;8;3;8;13)x2, der(?)t(8;14), der(8)t(8;21), der(?)t(X;8)x2, der(?)t(20;3;8;17;19;8;3;13), 9x2, 10x1, del(10), der(10?)t(6;4;6;10), 11x4, 12x2, der(12)t(3;12)(?;q23)x2, 13x1, der(13)t(13;20), der(14)t(5;14), der(?)t(9;14), 15x2, del(15), der(15)t(15;17), 16x2, der(16)t(7;16)x2, 17x1, der(?)t(20;19;8;17), 18x2, del(18), 19x1, der(?)t(19;22), 20x3, 21x3, 22x2, Xx2 cp[10]
CGH results  




Breast Cell Lines