Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC70

HCC70   [Cellosaurus entry CVCL_1270]

Breast Cancer Cell Line


A tetraploid cell line from mammary gland; breast; duct; primary ductal carcinoma, held at ATCC, included in the Cancer Genome Project at the Sanger Institute.

Notable Features

Tetraploid with 15 structural chromosome rearrangements, 5 of which whole arm translocations involving chromosomes 7, 8, 9, 11, 21, four involving chromosome 8. Losses involve chromosomes X, 4, 5(q31-qter), 6q, 8px3, 10q, 11px2, 12, 13, 15, 17; gains involve chromosomes 1, 3, 7, 7, 8q, 10p, 14, 16,16, 19, 21x3, 22.

Representative SKY Karyotype

97(89-97) XX, 1x5, der(1)t(X;1q)x2, 2x3, der(2)t(2p;7?), 3x5, 4x3, 5x3, der(5)del(5)(q31-qter)x3, 6x3, der(6)t(6p;22), 7x6, der(7-8)(q10;p10), 8x1, der(1-8)t(1;8), der(8;21)(q10;q10), der(8-9)(q10;p10)x2, 9x2, der(9-10)t(9;10)x2, der(9)t(9;16)a, der(9)del(9)x2, 10x3, i(10p), 11x2, der(9-11) )(p10;q10)x2, 12x3, 13x1, i(13q), 14x5, 15x3, 16x6, 17x3, 18x4, 19x5, 20x3, der(20)t(5;20), 21x1, 22x2

 a in less than 50% of the cells




Breast Cancer Cell Lines