Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > T-47D

T-47D   [Cellosaurus entry CVCL_0553]

Breast Carcinoma Cell Line

Description A highly rearranged, near triploid cell line, held at the ATCC and obtained from the ECACC.
Notable Features Translocations involve chromosomes 1, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 20 and X. Five markers have been duplicated. Deletions were detected on chromosomes 3, 10 (duplicated), 11 (duplicated), 12 and 18.
Representative SKY Karyotype
62(44-66).1x2, der(16)t(1;16), 2x2, 3x2, del(3)(p?), der(?)ins(3;5), 4x2, der(?)t(4;5), 5x2, 6x2, 7x2, der(7)t(7;15)x2, 8x2, der(8)t(8;14)x2, 9x2, der(9)t(9;17)x2, der(10)t(10;20), der(10)t(10;20), der(10)t(3;10)x2, del(10)x2, 11x2, del(11)(p?)x2, 12x1, der(12)t(12;16), der(12)t(12;13), del(12)(p?), 13x2, 14x2, 15x1, der(?)ins(15;9)x2, 16x2, 17x2, 18x2, del(18), 19x2, 20x2, 21x2, 22x2, Xx1, der(X)t(X;6) cp[10]
CGH results  




Breast Cell Lines