Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > MDA-MB-134
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Breast Carcinoma Cell Line |
Description | A hypodiploid cell line which appears to have undergone a monosomic pattern of evolution. It is held at the ATCC and was obtained from Dr Mike O'Hare. |
Notable Features | Translocations involve chromosomes 8, 11, 15, 16, 17 and 18, and of note is the duplicated marker with coamplification of 8 and 11. The 2nd larger clone has duplicated its chromosomes, but some chromosomes and markers have been lost. However, there has been a gain of chromosome 16. |
Representative SKY Karyotype | ![]() |
44 (37-47) and 66(60-77).1x2, 2x2, 3x2, 4x2, 5x2, 6x2, 7x1, 8x2, der(?)t(8;11)ins(11;8)nx2, 9x2, 10x2, 11x1, 12x2, 13x1, 14x2, 15x1, der(?)t(15;17), 16x1, 17x1, 18x1, der(18)t(16;18), 19x2, 20x2, 21x2, 22x2, Xx2 cp[8]/ idem x2, -1, -5x2, +16x2, +18, -X, -der(?)t(8;11)ins(8;11)n [7] | |
CGH results | |
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Additional Information | ![]() |