Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > MDA-MB-134

MDA-MB-134   [Cellosaurus entry CVCL_0617]

Breast Carcinoma Cell Line

Description A hypodiploid cell line which appears to have undergone a monosomic pattern of evolution. It is held at the ATCC and was obtained from Dr Mike O'Hare.
Notable Features Translocations involve chromosomes 8, 11, 15, 16, 17 and 18, and of note is the duplicated marker with coamplification of 8 and 11. The 2nd larger clone has duplicated its chromosomes, but some chromosomes and markers have been lost. However, there has been a gain of chromosome 16.
Representative SKY Karyotype
44 (37-47) and 66(60-77).1x2, 2x2, 3x2, 4x2, 5x2, 6x2, 7x1, 8x2, der(?)t(8;11)ins(11;8)nx2, 9x2, 10x2, 11x1, 12x2, 13x1, 14x2, 15x1, der(?)t(15;17), 16x1, 17x1, 18x1, der(18)t(16;18), 19x2, 20x2, 21x2, 22x2, Xx2 cp[8]/ idem x2, -1, -5x2, +16x2, +18, -X, -der(?)t(8;11)ins(8;11)n [7]
CGH results  

Additional Information



Breast Cell Lines