Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC38

HCC38   [Cellosaurus entry CVCL_1267]

Breast Cancer Cell Line


A hypertriploid cell line from mammary gland; breast; duct; primary ductal carcinoma, held at ATCC, included in the Cancer genome Project at the Sanger Institute.

Notable Features

Hypertriploid, extremely rearranged with 37 structural chromosome abnormalities, involving all chromosomes except 6 and 16, many of them in two copies, the majority complex involving more than three chromosomes, all cells contain hsr involving chromosome 8. Losses involve Xp, 6, 9, 12qx2; gains involve 5, 8, 16, 20. No normal chromosomes 1, 2, 3, 4, 5, 7, 8, 12, 15, 17, 18.

Representative SKY Karyotype

73(70-79), X, der(X)t(X;12;4), der(X)t(10;X;3), der(1;5)(q10;p10)x2, der(1)t(1;11;8)x2, der(1)t(4;12;1;7;3), der(2)t(2;10)x2, der(2)del(2)x2, der(3)t(3;15), der(3)t(3;15)x2, der(3;1;8), der(3)del(3), der(4)t(11;4;11)x2, der(4)t(4;9), der(5)t(3;5)x2 del(5)(q1-qter), 6x2, der(7)t(1;7), der(7)t(1;7;10), del(7)(p1-pter)x2, der(8)t(18;8;18)x2, 9x2, der(9)(del), 10x1, der(10)t(3;10), 11x1, der(12)t(12;8;14)(q24;hsr8;?), der(12)del(12)(q10-qter)x2, 13x1, der(13)del(13)x3, der(14-21) (q10;q10)x2, der(15)t(X;15), isodel(15), 16x3, der(17)t917;3;5)x2, der(17?)t(10/X;17;1), der(17)t(3;17), der(18)t(8;18;22), der(18;22;?), der(18)t(18;6), 19x1, der(19)t(19;3;19), der(19)t(19;1;9), 20x4, der(20)t(4;20;13;?), 21x1, 22x1, der(22)t(4:22)a.

a   in less than 50% of the cells




Breast Cancer Cell Lines