Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1569

HCC1569   [Cellosaurus entry CVCL_1255]

Breast Cancer Cell Line


A near hexaploid cell line from mammary gland; breast; primary metastatic carcinoma, derived from a patient with a germline mutation in FHIT gene at 3p13.2, held at ATCC, included in the Cancer Genome Project at the Sanger Institute.

Notable Features

A near-hexaploid cell line with 38 structural chromosome abnormalities, several rearrangements involving chromosome 8, some cells with dmin, hsr involving chr 19. Losses involve chromosomes X, 4, 6, 9, 10, 10 q, 11, 12, 13, 14, 15, 16, 18; gains involve chromosomes 7, 8, 19hsr, 20, 22.

Representative SKY Karyotype

130(126-133), XXX, der(X)t(X;10), 1x3, der(1)t(1;9)dup(1), i(1q)x2, 2x6, der(2)del(2), 3x4, der(3)t(3;15), isoder(3;15), der(3)del(3)(p21-pter), 4x3, der(4)t(4;17), der(4)t(4;6;?), 5x5, der(5)del(5), 6x3, der(6)t(6;11;19;20), 7x7, der(7)del(7), 8x6, der(8)t(8;17)t(p11-12;?), der(8)t(3;8), der(8)t(8;11), der(8)t(8;21), der(8)t(3;8;21), der(8)t(5;8), der(8)t(1;8), 9x3, der(9)del(9), 10x4, der(10;21)(p10;q10), 11x4, dup(11), 12x3, der(12)t(1;12), der(12)t(6;12), der(12)del(12), 13x2, der(13)t(13;19;20)dup19x2, 14x4, 15x4, 16x3, der(16)t(1;16)a, 17x3, der(17)t(17;18), del(17)?, 18x3, der(18)t(18;3;10)x2, 19x3, der(19)t(19;15;20)x2, 20x6, der(20)t(20;?20), der(20)t(20;X;2)?, der(20)t(7;20), 21x4, 22x6, der(22)t(16;22)x2, der(22)t(6;22)a, der(22)t(5;22) a

a in less than 50% of the cells    



Breast Cancer Cell Lines