Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1500

HCC1500   [Cellosaurus entry CVCL_1254]

Breast Cancer Cell Line


A hypodiploid cell line from mammary gland; breast; primary ductal carcinoma, held at ATCC, included in Cancer Genome Project at the Sanger Institute.

Notable Features

Hypodiploid, extremely rearranged with 17 structural chromosome abnormalities. No normal chromosomes 1, 8, 11, X. Losses involve X, 2q, 4, 8, 13, 14, 15, 17.

Representative SKY Karyotype

38(35-39) X, -X, der(X)t(X;5;1), der(1)t(X;1), der(1)del(1)(p21-pter), 2x1, der(2)t(2;20), 3x1, t(3;17), 4x1, der(4)t(4;8)a, 5x1, t(5;8;20), 6x1, der(6)t(6;17)(), 7x1, der(7)t(7;15)( p15?;?), der(8)t(5;8)(?;p21?), 9x1, der(9)t(8;9)(?;p21?), 10x1, der(10)t(3;10), der(11)t(10;11;6), der(11)t(11;12)dup(12), 12x1, 13x1, 14x1, i(14q) a, 15x1, 16x2, 17x1, 18x2, 19x2, 20x1, der(20)t(11;20), 21x2, 22x1, der(22)t(8;22)(q12;?)

a   in less than 50% of the cells




Breast Cancer Cell Lines