Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1419

HCC1419   [Cellosaurus entry CVCL_1251]

Breast Cancer Cell Line


A hypertriploid cell line from mammary gland, breast, primary ductal carcinoma, held at the ATCC, included in the Cancer Genome Project at the Sanger institute.

Notable Features

Hypertriploid, with 24 structural chromosome rearrangements, some cells with dmin, all cells have long hsrs involving chromosomes 8, 11, 20. Losses involve chromosomes X, 17, 18; gains involve 3, 4, 5p, 6, 8, 9, 11hsr, 12, 19, 20hsr, 21, 22.

Representative SKY Karyotype

74(66-79), XX, 1x2, der(1)t(1;20), der(1)t(1;16), der(1)t(1;8;4;11;9?), 2x1, der(2)t(2;3), der(2)t(2;3?;5)dup(2), 3x2, der(3)t(3;2;3;13), der(3)del(3), 4x3, der(4)del(4)t(4;11;13), 5x3, der(5)del(5)(q10-qter), i(5p)?, del(5)t(5;11), 6x4, 7x2, der(7)del(7)t(7;16), der(7)t(7;11), der(7)del(7), 8x2, der(8)t(8;11)hsr8qx2, 9x1, der(9?)t(9;11), 10x3, 11x1, der(11)t(9;11), der(11?)t(9;11;20;9)hsr11;hsr20, 12x4, 13x2, der(13)t(5;13)(?;q14-q21), 14x1, der(11;14)(p10-q10)x2, 15x2, 16x2, der(16)t(10;16), der(17)t(4;17), der(17)t(17;4;17;15), 18x2, 19x4, 20x1, der(20)t(7;20), 21x4, 22x4




Breast Cancer Cell Lines