Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1187

HCC1187   [Cellosaurus entry CVCL_1247]

Breast Cancer Cell Line


A hypotriploid cell line from mammary gland; breast; duct; primary ductal carcinoma, held at ATCC, included in Cancer Genome Project at the Sanger Institute.

Notable Features

Hypotriploid, with 20 structural chromosome abnormalities, including two reciprocal translocations – t(1;8) and t(10;13). All cells contain dmin involving chromosomes 1;5;22. No normal chromosomes 1, 2, 13. Losses involve 3, 4, 5, 6, 12, 14, 15, 16, 17, 20; gains involve 7, dup (18).

Representative SKY Karyotype

63(61-64), X, der(X)t(X;1;6), isoder(X;1), der(1)t(1;6), der(1)t(1;8)(q12;q?)*, der(2)t(2;20)x2, der(2?)t(2;19), der(2)del(2)t(2;5), 3x2, 4x2, 5x2, 6x2, 7x4, 8x1, der(8)t(1;8)*, der(8)t(1;8;1), 9x3, 10x2, der(10)t10;13)**, 11x2, der(11)t(1;11), der(11)t(11;12), 12x2, del(13), isodel(13), der(13)t(10;13)**x3, 14x2, 15x2, 16x1, der(16)t(16;6/12), 17x2, 18x2, dup(18), 19x1, der(19)t(2;19), del(19), 20x1, der(20)t(14;20), 21x3, 22x2, dmin(22),* and **reciprocal translocations a   in less than 50% of the cells




Breast Cancer Cell Lines