Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > DU4475

DU4475   [Cellosaurus entry CVCL_1183]

Breast Cancer Cell Line


Karyotype Features

From a skin nodule presumed metastatic from a breast cancer. One of the less highly rearranged breast cancer cell line karyotypes. Modal number is approximately tetraploid, and a number of translocations are present in two copies, strongly suggesting recent endoreduplication. The presence of APC and BRAF mutations in this line (see Cancer Genome Project, Sanger Institute) is untypical of breast and raises the possibility that this is a colorectal line.

Representative SKY Karyotype

Mode 91. 1x4, i(1q)x2, 2x4, 3x3, der(3)t(3:15), 4x3, 5x2, der(5)t(5:20)x2, der(5)t(5:20)x2, 6x1, der(6)t(6:21)x2, 7x5, 8x4, 9x4, 10x2, der(10)t(10:21)x2, der(10)t(10:X), 11x3, der(11)t(11:3:5), 12x4, 13x4, 14x3, 15x3, 16x2, 17x2, der(17)t(17:16)x2, 18x3, 19x4, 20x2*, 21x1, 22x3, Xx4

*~50%cells have 20x1, der(20)t(20:4)




Breast Cancer Cell Lines