Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > BT20

BT20   [Cellosaurus entry CVCL_0178]

Breast Cancer Cell Line

 

Description

 

 

Notable Features

Hyperdiploid, highly rearranged, with 30 structural rearrangements, some of them complex, with amplified region of chromosomes 6, 11, 20, most cells have double minutes (DMs), most involving chromosome1, some – chromosome 5. Losses involve chromosomes X, 1p, 8p, 10, 14, 17p; gains involve chromosomes 1q, 2, 7p, 20, 21.

 

 

Representative SKY Karyotype

 

 

 

 

48 (47-50) X, 1x1, der(1-14)(q10;q10), der(1)t(1q;5q;12), 2x1, der(2)t(2;8), der(2)t(X;2)dup(2), der(2)t(2;5)?, 3x1, der(3)del(3), der(3?)t(15;14;6?;3;9), 4x2, der(5)del(5)t(3;5), 6x1, der(6)t(6;7;6)(q23;?;q22-qter)dup(6)(q22-qter), 7x2, der(6-7)t(6;7p), i(7p), 8x1, der(8)t(16/5?;8q;5q), der(9?)t(der(9)t(X;9)?, der(9)t(9;10), der(9)t(5/16)dic(9-9), der(10)del(10)(q11-qter), der(10)t(X;10), der(10?)t(10;20)?, 11x1, der(11)t(5;11q)dup(11)(q14-qter), 12x1, der(12)t(12;2/X;12), 13x1, der(13)t(8;13q); der(14)del(14), 15x1, der(15)t(14;15), 16x1, der(16)t(3;16), 17x1, der(17)del(17)(p11-pter), 18x1, der(18)t(7;18), 19x1, der(19)dic(11;19; 11;1;11;13), 20x1, der(20)t(20;X;10;X;20)dup(20), 21x1, dic(21-21), 22x1, der(22)t(1;22), dmin

 

 

 

Additional Information

 

 

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Breast Cancer Cell Lines