ID 109MA AC CVCL_ZT99 SY 109 MAnchester DR Wikidata; Q98125017 RX PubMed=9649131; CC Senescence: Senesces at 64 PDL (PubMed=9649131). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu180Lys (c.538G>A); ClinVar=VCV000245711; Zygosity=Heterozygous (PubMed=9649131). CC Donor information: At sampling donor was not affected with Li-Fraumeni syndrome. CC Derived from site: In situ; Skin; UBERON=UBERON_0002097. CC Cell type: Fibroblast of skin; CL=CL_0002620. DI NCIt; C3476; Li-Fraumeni syndrome DI ORDO; Orphanet_524; Li-Fraumeni syndrome OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 52Y CA Finite cell line DT Created: 02-07-20; Last updated: 19-12-24; Version: 8 // RX PubMed=9649131; DOI=10.1038/bjc.1998.364; PMCID=PMC2150396; RA Boyle J.M., Mitchell E.L.D., Greaves M.J., Roberts S.A., Tricker K., RA Burt E., Varley J.M., Birch J.M., Scott D.; RT "Chromosome instability is a predominant trait of fibroblasts from RT Li-Fraumeni families."; RL Br. J. Cancer 77:2181-2192(1998). //