ID   105MA
AC   CVCL_ZT98
SY   105 MAnchester
DR   Wikidata; Q98110437
RX   PubMed=8794843;
RX   PubMed=9018113;
RX   PubMed=9649131;
RX   PubMed=9681890;
CC   Senescence: Senesces at 34 PDL (PubMed=9649131).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   58Y
CA   Finite cell line
DT   Created: 02-07-20; Last updated: 30-01-24; Version: 7
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RX   PubMed=8794843; DOI=10.1080/095530096145139;
RA   Sproston A.R.M., Boyle J.M., Heighway J., Birch J.M., Scott D.;
RT   "Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate
RT   irradiation.";
RL   Int. J. Radiat. Biol. 70:145-150(1996).
//
RX   PubMed=9018113; DOI=10.1038/sj.onc.1200838;
RA   Williams K.J., Boyle J.M., Birch J.M., Norton J.D., Scott D.;
RT   "Cell cycle arrest defect in Li-Fraumeni syndrome: a mechanism of
RT   cancer predisposition?";
RL   Oncogene 14:277-282(1997).
//
RX   PubMed=9649131; DOI=10.1038/bjc.1998.364; PMCID=PMC2150396;
RA   Boyle J.M., Mitchell E.L.D., Greaves M.J., Roberts S.A., Tricker K.,
RA   Burt E., Varley J.M., Birch J.M., Scott D.;
RT   "Chromosome instability is a predominant trait of fibroblasts from
RT   Li-Fraumeni families.";
RL   Br. J. Cancer 77:2181-2192(1998).
//
RX   PubMed=9681890; DOI=10.1016/S0167-8140(97)00200-4;
RA   Zhou P.-K., Sproston A.R.M., Marples B., West C.M.L., Margison G.P.,
RA   Hendry J.H.;
RT   "The radiosensitivity of human fibroblast cell lines correlates with
RT   residual levels of DNA double-strand breaks.";
RL   Radiother. Oncol. 47:271-276(1998).
//