ID   HT1080-MFAP4 W235F-MH
AC   CVCL_ZJ81
DR   cancercelllines; CVCL_ZJ81
DR   Wikidata; Q98126738
RX   PubMed=32442478;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7035; MFAP4 (Note=With p.Trp235Phe and a C-terminal mycHis6 tag).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
DI   NCIt; C3043; Fibrosarcoma
DI   ORDO; Orphanet_2030; Fibrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0317 ! HT-1080
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 19-12-24; Version: 11
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RX   PubMed=32442478; DOI=10.1016/j.bbagen.2020.129637;
RA   Osada Y., Suzuki T., Mizuta H., Mori K., Miura K., Dohmae N.,
RA   Simizu S.;
RT   "The fibrinogen C-terminal domain is seldom C-mannosylated but its
RT   C-mannosylation is important for the secretion of
RT   microfibril-associated glycoprotein 4.";
RL   Biochim. Biophys. Acta 1864:129637.1-129637.8(2020).
//