ID   LanthaScreen ERK2 A375
AC   CVCL_ZJ05
DR   cancercelllines; CVCL_ZJ05
DR   Wikidata; Q98126851
WW   Provider; Thermo Fisher; K1798; https://www.thermofisher.com/order/catalog/product/K1798
CC   Population: Caucasian.
CC   Characteristics: Transfected with an EmGFP-MAPK1/ERK2 construct whose expression is under the control of a CMV promoter.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=FPbase; GLAD6; Emerald (Note=EmGFP, green fluorescent protein derived from GFP).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6871; MAPK1.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 10-04-25; Version: 11
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