ID   Mel 04.01
AC   CVCL_ZD03
SY   MEL04.01; 04.01
DR   cancercelllines; CVCL_ZD03
DR   PRIDE; PXD000497
DR   Wikidata; Q98127208
RX   PubMed=23685455;
RX   PubMed=25538140;
RX   PubMed=27350335;
CC   From: Leiden University Medical Center; Leiden; Netherlands.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23685455; PubMed=25538140).
CC   Sequence variation: Mutation; HGNC; HGNC:1424; CAD; Simple; p.Arg1854Gln (c.5561G>A); ClinVar=VCV001481207; Zygosity=Heterozygous (PubMed=27350335).
CC   Sequence variation: Mutation; HGNC; HGNC:3330; EML1; Simple; p.Arg64Trp (c.190C>T); Zygosity=Heterozygous (PubMed=27350335).
CC   Sequence variation: Mutation; HGNC; HGNC:8761; PDCD10; Simple; p.Pro28Ser (c.82C>T); Zygosity=Homozygous (PubMed=27350335).
CC   Sequence variation: Mutation; HGNC; HGNC:30400; SEMA3G; Simple; p.Arg300Cys (c.898C>T); Zygosity=Heterozygous (PubMed=27350335).
CC   Omics: Proteomics.
CC   Omics: Proteomics; PTM; Phosphorylation.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_ZD06 ! Mel 12.07
SX   Male
AG   42Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 10-04-25; Version: 8
//
RX   PubMed=23685455; DOI=10.1038/nature12154;
RA   Kaplon J., Zheng L., Meissl K., Chaneton B., Selivanov V.A.,
RA   Mackay G., van der Burg S.H., Verdegaal E.M.E., Cascante M., Shlomi T.,
RA   Gottlieb E., Peeper D.S.;
RT   "A key role for mitochondrial gatekeeper pyruvate dehydrogenase in
RT   oncogene-induced senescence.";
RL   Nature 498:109-112(2013).
//
RX   PubMed=25538140; DOI=10.15252/msb.20145450; PMCID=PMC4300494;
RA   Smit M.A., Maddalo G., Greig K., Raaijmakers L.M., Possik P.A.,
RA   van Breukelen B., Cappadona S., Heck A.J.R., Altelaar A.F.M.,
RA   Peeper D.S.;
RT   "ROCK1 is a potential combinatorial drug target for BRAF mutant
RT   melanoma.";
RL   Mol. Syst. Biol. 10:772-772(2014).
//
RX   PubMed=27350335; DOI=10.1038/nature18945;
RA   Verdegaal E.M.E., de Miranda N.F.C.C., Visser M., Harryvan T.,
RA   van Buuren M.M., Andersen R.S., Hadrup S.R., van der Minne C.E.,
RA   Schotte R., Spits H., Haanen J.B.A.G., Kapiteijn E.H.W.,
RA   Schumacher T.N., van der Burg S.H.;
RT   "Neoantigen landscape dynamics during human melanoma-T cell
RT   interactions.";
RL   Nature 536:91-95(2016).
//