ID   RML-12
AC   CVCL_Z829
SY   RML12
DR   Wikidata; Q54950676
RX   PubMed=2563994;
RX   PubMed=6137452;
RX   PubMed=18836024;
RX   PubMed=19951376;
RX   PubMed=20976219;
RX   PubMed=26519596;
RX   PubMed=29973702;
CC   Group: Insect cell line.
CC   Problematic cell line: Misidentified. Originally thought to be of Aedes aegypti origin but found to be from Aedes albopictus (PubMed=19951376; PubMed=29973702).
OX   NCBI_TaxID=7160; ! Aedes albopictus (Asian tiger mosquito)
SX   Sex unspecified
AG   Larval stage
CA   Spontaneously immortalized cell line
DT   Created: 10-04-15; Last updated: 21-03-23; Version: 8
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RX   PubMed=2563994; DOI=10.1007/BF02626177;
RA   Kuno G., Oliver A.;
RT   "Maintaining mosquito cell lines at high temperatures: effects on the
RT   replication of flaviviruses.";
RL   In Vitro Cell. Dev. Biol. 25:193-196(1989).
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RX   PubMed=6137452; DOI=10.1007/BF02628962;
RA   Kuno G.;
RT   "Cultivation of mosquito cell lines in serum-free media and their
RT   effects on dengue virus replication.";
RL   In Vitro 19:707-713(1983).
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RX   PubMed=18836024; DOI=10.1128/AEM.01038-08;
RA   McMeniman C.J., Lane A.M., Fong A.W.C., Voronin D.A.,
RA   Iturbe-Ormaetxe I., Yamada R., McGraw E.A., O'Neill S.L.;
RT   "Host adaptation of a Wolbachia strain after long-term serial passage
RT   in mosquito cell lines.";
RL   Appl. Environ. Microbiol. 74:6963-6969(2008).
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RX   PubMed=19951376; DOI=10.1111/j.1365-2672.2009.04621.x;
RA   Voronin D.A., Tran-Van V., Potier P., Mavingui P.;
RT   "Transinfection and growth discrepancy of Drosophila Wolbachia strain
RT   wMel in cell lines of the mosquito Aedes albopictus.";
RL   J. Appl. Microbiol. 108:2133-2141(2010).
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RX   PubMed=20976219; DOI=10.1371/journal.pone.0013398;
RA   Frentiu F.D., Robinson J., Young P.R., McGraw E.A., O'Neill S.L.;
RT   "Wolbachia-mediated resistance to dengue virus infection and death at
RT   the cellular level.";
RL   PLoS ONE 5:E13398-E13398(2010).
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RX   PubMed=26519596; DOI=10.1016/j.virol.2015.07.021;
RA   McLean B.J., Hobson-Peters J., Webb C.E., Watterson D., Prow N.A.,
RA   Nguyen H.D., Hall-Mendelin S., Warrilow D., Johansen C.A.,
RA   Jansen C.C., van den Hurk A.F., Beebe N.W., Schnettler E.,
RA   Barnard R.T., Hall R.A.;
RT   "A novel insect-specific flavivirus replicates only in Aedes-derived
RT   cells and persists at high prevalence in wild Aedes vigilax
RT   populations in Sydney, Australia.";
RL   Virology 486:272-283(2015).
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RX   PubMed=29973702; DOI=10.1038/s41598-018-28357-2;
RA   Gaburro J., Duchemin J.-B., Paradkar P.N., Nahavandi S., Bhatti A.;
RT   "Electrophysiological evidence of RML12 mosquito cell line towards
RT   neuronal differentiation by 20-hydroxyecdysdone.";
RL   Sci. Rep. 8:10109-10109(2018).
//