ID   BmN4
AC   CVCL_Z634
SY   BmN-4; BM-N4
DR   BTO; BTO:0005690
DR   ICLDB; bmn4
DR   NISES; SK0023
DR   Wikidata; Q54797601
RX   PubMed=10358729;
RX   PubMed=10585188;
RX   PubMed=15827172;
RX   PubMed=16756546;
RX   PubMed=22714272;
RX   PubMed=24934233;
RX   PubMed=33023468;
CC   Group: Insect cell line.
CC   Virology: Infected by Bombyx mori macula-like latent virus (BmMLV).
CC   Doubling time: 73.3 hours (PubMed=24934233); 58 +- 6 hours (Note=In static culture), 72 +- 2 hours (Note=In suspension culture) (PubMed=10585188).
CC   Omics: Deep proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
OX   NCBI_TaxID=7091; ! Bombyx mori (Silk moth)
HI   CVCL_Z633 ! BM-N
SX   Female
CA   Spontaneously immortalized cell line
DT   Created: 10-04-15; Last updated: 29-06-23; Version: 12
//
RX   PubMed=10358729;
RA   Yanase T., Yasunaga C., Kawarabata T.;
RT   "Replication of Spodoptera exigua nucleopolyhedrovirus in permissive
RT   and non-permissive lepidopteran cell lines.";
RL   Acta Virol. 42:293-298(1998).
//
RX   PubMed=10585188; DOI=10.1021/bp990119f;
RA   Keith M.B., Farrell P.J., Iatrou K., Behie L.A.;
RT   "Screening of transformed insect cell lines for recombinant protein
RT   production.";
RL   Biotechnol. Prog. 15:1046-1052(1999).
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RX   PubMed=15827172; DOI=10.1128/JVI.79.9.5577-5584.2005;
RA   Katsuma S., Tanaka S., Omuro N., Takabuchi L., Daimon T., Imanishi S.,
RA   Yamashita S., Iwanaga M., Mita K., Maeda S., Kobayashi M.,
RA   Shimada T.;
RT   "Novel macula-like virus identified in Bombyx mori cultured cells.";
RL   J. Virol. 79:5577-5584(2005).
//
RX   PubMed=16756546; DOI=10.1111/j.1365-2583.2006.00639.x;
RA   Taniai K., Lee J.-H., Lee I.-H.;
RT   "Bombyx mori cell line as a model of immune-system organs.";
RL   Insect Mol. Biol. 15:269-279(2006).
//
RX   PubMed=22714272; DOI=10.1007/s10529-012-0971-y;
RA   Lee J.M., Kawakami N., Mon H., Mitsunobu H., Iiyama K., Ninaki S.,
RA   Maenaka K., Park E.Y., Kusakabe T.;
RT   "Establishment of a Bombyx mori nucleopolyhedrovirus (BmNPV)
RT   hyper-sensitive cell line from the silkworm e21 strain.";
RL   Biotechnol. Lett. 34:1773-1779(2012).
//
RX   PubMed=24934233; DOI=10.1007/s11626-014-9781-y;
RA   Iwanaga M., Adachi Y., Uchiyama K., Tsukui K., Katsuma S.,
RA   Kawasaki H.;
RT   "Long-term adaptation of the Bombyx mori BmN4 cell line to grow in
RT   serum-free culture.";
RL   In Vitro Cell. Dev. Biol. Anim. 50:792-796(2014).
//
RX   PubMed=33023468; DOI=10.1186/s12864-020-07088-7;
RA   Levin M., Scheibe M., Butter F.;
RT   "Proteotranscriptomics assisted gene annotation and spatial proteomics
RT   of Bombyx mori BmN4 cell line.";
RL   BMC Genomics 21:690.1-690.14(2020).
//