ID   Aag-2
AC   CVCL_Z617
SY   Aag2; Peleg's line 59; 59; AA-P
DR   BTO; BTO:0006292
DR   PRIDE; PXD010191
DR   PRIDE; PXD033231
DR   Wikidata; Q54607594
RX   CelloPub=CLPUB00492;
RX   DOI=10.1303/aez.13.170;
RX   PubMed=627872;
RX   PubMed=2267971;
RX   PubMed=4869110;
RX   PubMed=5142332;
RX   PubMed=22827926;
RX   PubMed=28497119;
RX   PubMed=32807211;
RX   PubMed=34878970;
WW   https://www.vectorbase.org/organisms/aedes-aegypti/aag2/aag2
WW   https://www.vectorbase.org/vbsearch/details/VBRNAseq_group_1243
CC   Group: Insect cell line.
CC   Doubling time: ~24 hours (PubMed=627872).
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by RNAseq.
OX   NCBI_TaxID=7159; ! Aedes aegypti (Yellowfever mosquito)
SX   Sex unspecified
AG   Neonate larva
CA   Spontaneously immortalized cell line
DT   Created: 10-04-15; Last updated: 29-06-23; Version: 16
//
RX   CelloPub=CLPUB00492;
RA   Mitsuhashi J.;
RT   "Nutritional requirements of insect cells in vitro.";
RL   (In) Invertebrate cell system applications, Vol. I; Mitsuhashi J. (eds.); pp.3-20; CRC Press; Boca Raton (1989).
//
RX   DOI=10.1303/aez.13.170;
RA   Mitsuhashi J.;
RT   "Amino acid requirements of some continuous cell lines of insects.";
RL   Appl. Entomol. Zool. 13:170-175(1978).
//
RX   PubMed=627872; DOI=10.1099/0022-1317-38-2-231;
RA   Peleg J., Pecht M.;
RT   "Adaptation of an Aedes aegypti mosquito cell line to growth at 15
RT   degrees C and its response to infection by Sindbis virus.";
RL   J. Gen. Virol. 38:231-239(1978).
//
RX   PubMed=2267971; DOI=10.4269/ajtmh.1990.43.669;
RA   Lan Q., Fallon A.M.;
RT   "Small heat shock proteins distinguish between two mosquito species
RT   and confirm identity of their cell lines.";
RL   Am. J. Trop. Med. Hyg. 43:669-676(1990).
//
RX   PubMed=4869110; DOI=10.4269/ajtmh.1968.17.219;
RA   Peleg J.;
RT   "Growth of arboviruses in primary tissue culture of Aedes aegypti
RT   embryos.";
RL   Am. J. Trop. Med. Hyg. 17:219-223(1968).
//
RX   PubMed=5142332; DOI=10.1007/978-3-642-65224-0_1;
RA   Schneider I.;
RT   "The culture of cells from insects and ticks. I. Cultivation of
RT   dipteran cells in vitro.";
RL   Curr. Top. Microbiol. Immunol. 55:1-12(1971).
//
RX   PubMed=22827926; DOI=10.1186/1756-3305-5-148;
RA   Barletta A.B.F., Silva M.C.L.N., Sorgine M.H.F.;
RT   "Validation of Aedes aegypti Aag-2 cells as a model for insect immune
RT   studies.";
RL   Parasit. Vectors 5:148.1-148.9(2012).
//
RX   PubMed=28497119; DOI=10.1128/mSphere.00144-17;
RA   Varjak M., Maringer K., Watson M., Sreenu V.B., Fredericks A.C.,
RA   Pondeville E., Donald C.L., Sterk J., Kean J., Vazeille M.,
RA   Failloux A.-B., Kohl A., Schnettler E.;
RT   "Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in
RT   antiviral responses.";
RL   mSphere 2:e00144.17.1-e00144.17.16(2017).
//
RX   PubMed=32807211; DOI=10.1186/s13071-020-04294-w;
RA   Li M.-J., Lan C.-J., Gao H.-T., Xing D., Gu Z.-Y., Su D., Zhao T.-Y.,
RA   Yang H.-Y., Li C.-X.;
RT   "Transcriptome analysis of Aedes aegypti Aag2 cells in response to
RT   dengue virus-2 infection.";
RL   Parasit. Vectors 13:421.1-421.14(2020).
//
RX   PubMed=34878970; DOI=10.1099/jgv.0.001700;
RA   de Oliveira A.S., Vasconcellos A.F., Rodrigues B.M.P., da Silva L.A.,
RA   Resende R.O., Ribeiro B.M.;
RT   "Chikungunya virus produced by a persistently infected mosquito cell
RT   line comprises a shorter genome and is non-infectious to mammalian
RT   cells.";
RL   J. Gen. Virol. 102:001700.1-001700.11(2021).
//