ID   Caco-2/AQ
AC   CVCL_Z585
SY   Caco2/AQ
DR   BTO; BTO:0005666
DR   cancercelllines; CVCL_Z585
DR   Wikidata; Q54808324
RX   PubMed=9486194;
RX   PubMed=14599474;
RX   PubMed=15868485;
RX   PubMed=18205904;
RX   PubMed=22940288;
RX   PubMed=24176760;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0232 ! Caco-2/15
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 05-10-23; Version: 12
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RX   PubMed=9486194; DOI=10.1152/ajpgi.1998.274.2.G389;
RA   Chirayath M.V., Gajdzik L., Hulla W., Graf J., Cross H.S.,
RA   Peterlik M.;
RT   "Vitamin D increases tight-junction conductance and paracellular Ca2+
RT   transport in Caco-2 cell cultures.";
RL   Am. J. Physiol. 274:G389-G396(1998).
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RX   PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X;
RA   Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.;
RT   "Permeability characteristics of parental and clonal human intestinal
RT   Caco-2 cell lines differentiated in serum-supplemented and serum-free
RT   media.";
RL   Toxicol. In Vitro 17:761-767(2003).
//
RX   PubMed=15868485; DOI=10.1007/s10565-005-0085-6;
RA   Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A.,
RA   Zucco F.;
RT   "The Caco-2 cell line as a model of the intestinal barrier: influence
RT   of cell and culture-related factors on Caco-2 cell functional
RT   characteristics.";
RL   Cell Biol. Toxicol. 21:1-26(2005).
//
RX   PubMed=18205904; DOI=10.1186/1471-2407-8-13;
RA   Brozek W., Bises G., Fabjani G., Cross H.S., Peterlik M.;
RT   "Clone-specific expression, transcriptional regulation, and action of
RT   interleukin-6 in human colon carcinoma cells.";
RL   BMC Cancer 8:13.1-13.9(2008).
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RX   PubMed=22940288; DOI=10.1016/j.jsbmb.2012.08.003;
RA   Hobaus J., Fetahu I.S., Khorchide M., Manhardt T., Kallay E.;
RT   "Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase
RT   (CYP24A1) in colon cancer cells.";
RL   J. Steroid Biochem. Mol. Biol. 136:296-299(2013).
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RX   PubMed=24176760; DOI=10.1016/j.jsbmb.2013.10.015;
RA   Fetahu I.S., Hummel D.M., Manhardt T., Aggarwal A.,
RA   Baumgartner-Parzer S., Kallay E.;
RT   "Regulation of the calcium-sensing receptor expression by
RT   1,25-dihydroxyvitamin D3, interleukin-6, and tumor necrosis factor
RT   alpha in colon cancer cells.";
RL   J. Steroid Biochem. Mol. Biol. 144:228-231(2014).
//