AC   CVCL_Z182
SY   RML-15
DR   Wikidata; Q54950684
RX   Patent=US4447537;
RX   PubMed=7275139;
RX   PubMed=22743047;
RX   PubMed=26210950;
RX   PubMed=27484910;
RX   PubMed=29886187;
RX   PubMed=32158404;
CC   Group: Patented cell line.
CC   Group: Tick cell line.
CC   Problematic cell line: Misidentified. Originally thought to be of Dermacentor variabilis origin but found to be from Rhipicephalus sanguineus (PubMed=26210950).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00583.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8052.
OX   NCBI_TaxID=34632; ! Rhipicephalus sanguineus (Brown dog tick)
SX   Sex unspecified
AG   Embryo
CA   Spontaneously immortalized cell line
DT   Created: 10-04-15; Last updated: 02-05-24; Version: 11
RX   Patent=US4447537;
RA   Yunker C.E., Cory J.C., Meibos H.R.;
RT   "Tick cell lines.";
RL   Patent number US4447537, 08-May-1984.
RX   PubMed=7275139; DOI=10.1007/BF02618071;
RA   Yunker C.E., Cory J.C., Meibos H.R.;
RT   "Continuous cell lines from embryonic tissues of ticks (Acari:
RT   Ixodidae).";
RL   In Vitro 17:139-142(1981).
RX   PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002;
RA   Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K.,
RA   Kohl A., Bell-Sakyi L.;
RT   "Detection and identification of putative bacterial endosymbionts and
RT   endogenous viruses in tick cell lines.";
RL   Ticks Tick Borne Dis. 3:137-146(2012).
RX   PubMed=26210950; DOI=10.1016/j.vetmic.2015.07.008;
RA   Bell-Sakyi L., Palomar A.M., Bradford E.L., Shkap V.;
RT   "Propagation of the Israeli vaccine strain of Anaplasma centrale in
RT   tick cell lines.";
RL   Vet. Microbiol. 179:270-276(2015).
RX   PubMed=27484910; DOI=10.1186/s13071-016-1708-x;
RA   Koh-Tan H.H.C., Strachan E., Cooper K., Bell-Sakyi L., Jonsson N.N.;
RT   "Identification of a novel beta-adrenergic octopamine receptor-like
RT   gene (betaAOR-like) and increased ATP-binding cassette B10 (ABCB10)
RT   expression in a Rhipicephalus microplus cell line derived from
RT   acaricide-resistant ticks.";
RL   Parasit. Vectors 9:425.1-425.11(2016).
RX   PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015;
RA   Bell-Sakyi L., Darby A.C., Baylis M., Makepeace B.L.;
RT   "The Tick Cell Biobank: a global resource for in vitro research on
RT   ticks, other arthropods and the pathogens they transmit.";
RL   Ticks Tick Borne Dis. 9:1364-1371(2018).
RX   PubMed=32158404; DOI=10.3389/fphys.2020.00152;
RA   Al-Rofaai A., Bell-Sakyi L.;
RT   "Tick cell lines in research on tick control.";
RL   Front. Physiol. 11:152.1-152.7(2020).