ID   HPDE-iKRAS(G12D)
AC   CVCL_YY28
SY   HPDE-iKRASG12D
DR   Wikidata; Q98126697
RX   PubMed=26806015;
CC   Characteristics: Expression the KRAS gene is under the control of doxycycline.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6407; KRAS (Note=With p.Gly12Asp (c.35G>A)).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Donor information: Established from a patient suffering from a cystadenocarcinoma in the tail of her pancreas.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
CC   Cell type: Pancreatic ductal cell; CL=CL_0002079.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0P37 ! HPDE6c11
SX   Female
AG   63Y
CA   Transformed cell line
DT   Created: 02-07-20; Last updated: 10-04-25; Version: 12
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RX   PubMed=26806015; DOI=10.1038/ncomms10500; PMCID=PMC4737758;
RA   Tsang Y.H., Dogruluk T., Tedeschi P.M., Wardwell-Ozgo J., Lu H.-Y.,
RA   Espitia M., Nair N., Minelli R., Chong Z.-C., Chen F.-J., Chang Q.E.,
RA   Dennison J.B., Dogruluk A., Li M., Ying H.-Q., Bertino J.R.,
RA   Gingras M.-C., Ittmann M., Kerrigan J., Chen K., Creighton C.J.,
RA   Eterovic A.K., Mills G.B., Scott K.L.;
RT   "Functional annotation of rare gene aberration drivers of pancreatic
RT   cancer.";
RL   Nat. Commun. 7:10500.1-10500.11(2016).
//