ID   Huh7.5.1-8
AC   CVCL_YU20
DR   cancercelllines; CVCL_YU20
DR   Wikidata; Q94308759
RX   PubMed=25420655;
RX   PubMed=33193621;
CC   Population: Japanese.
CC   Virology: Highly susceptible to infection by hepatitis C virus (HCV).
CC   Sequence variation: Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (PubMed=33193621).
CC   Sequence variation: Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Heterozygous (PubMed=33193621).
CC   Sequence variation: Mutation; HGNC; HGNC:11255; SPP1; Simple; p.Lys241Thr (c.722A>C); Zygosity=Heterozygous; Note=Newly acquired mutation (PubMed=33193621).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Omics: Genomics; Whole genome sequencing.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E049 ! Huh-7.5.1
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 10-04-25; Version: 12
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RX   PubMed=33193621; DOI=10.3389/fgene.2020.546106; PMCID=PMC7581915;
RA   Kawamoto, Masaki
RA   Yamaji, Toshiyuki
RA   Saito, Kyoko
RA   Shirasago, Yoshitaka
RA   Satomura, Kazuhiro
RA   Endo, Toshinori
RA   Fukasawa, Masayoshi
RA   Hanada, Kentaro
RA   Osada, Naoki
RT   "Identification of characteristic genomic markers in human hepatoma
RT   Huh-7 and Huh7.5.1-8 cell lines.";
RL   Front. Genet. 11:546106.1-546106.10(2020).
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RX   PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231;
RA   Shirasago, Yoshitaka
RA   Sekizuka, Tsuyoshi
RA   Saito, Kyoko
RA   Suzuki, Tetsuro
RA   Wakita, Takaji
RA   Hanada, Kentaro
RA   Kuroda, Makoto
RA   Abe, Ryo
RA   Fukasawa, Masayoshi
RT   "Isolation and characterization of an Huh.7.5.1-derived cell clone
RT   highly permissive to hepatitis C virus.";
RL   Jpn. J. Infect. Dis. 68:81-88(2015).
//