ID   PK15 PERV-inactivated clone 15
AC   CVCL_YE75
SY   PK15 clone 15; PK15-15
DR   Wikidata; Q98128600
RX   PubMed=26456528;
RX   PubMed=31667881;
CC   Characteristics: Using CRISPR/Cas9 all 62 copies of the PERV pol gene were inactivated (PubMed=26456528).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Breed/subspecies: Hampshire; VBO=VBO_0001146.
OX   NCBI_TaxID=9823; ! Sus scrofa (Pig)
HI   CVCL_2160 ! PK-15
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 19-12-19; Last updated: 10-09-24; Version: 5
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RX   PubMed=31667881; DOI=10.1111/xen.12563;
RA   Godehardt, Antonia W.
RA   Fischer, Nicole
RA   Rauch, Paula
RA   Gulich, Barbara
RA   Boller, Klaus
RA   Church, George McDonald
RA   Tonjes, Ralf Reinhard
RT   "Characterization of porcine endogenous retrovirus particles released
RT   by the CRISPR/Cas9 inactivated cell line PK15 clone 15.";
RL   Xenotransplantation 27:e12563.1-e12563.12(2020).
//
RX   PubMed=26456528; DOI=10.1126/science.aad1191;
RA   Yang, Lu-Han
RA   Guell, Marc
RA   Niu, Dong
RA   George, Haydy
RA   Lesha, Emal
RA   Grishin, Dennis
RA   Aach, John
RA   Shrock, Ellen
RA   Xu, Wei-Hong
RA   Poci, Jurgen
RA   Cortazio, Rebeca
RA   Wilkinson, Robert A.
RA   Fishman, Jay A.
RA   Church, George McDonald
RT   "Genome-wide inactivation of porcine endogenous retroviruses
RT   (PERVs).";
RL   Science 350:1101-1104(2015).
//